Nakajima Koji, Ogawa Akitoshi, Kodama Hiroyasu, Shirokoshi Tomohiko, Osada Takahiro, Konishi Seiki, Horii Chiaki, Oshima Yasushi, Iidaka Toshiko, Muraki Shigeyuki, Oka Hiroyuki, Kawaguchi Hiroshi, Akune Toru, Hashizume Hiroshi, Yamada Hiroshi, Yoshida Munehito, Nakamura Kozo, Shojima Masaaki, Tanaka Sakae, Yoshimura Noriko
Department of Orthopaedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Neurophysiology, Juntendo University School of Medicine, Tokyo, Japan.
Geriatr Gerontol Int. 2025 Feb;25(2):279-286. doi: 10.1111/ggi.15033. Epub 2025 Jan 5.
This study aims to investigate the impact of aging on brain volume among community residents in Japan, focusing on trends over time and specific brain structures.
We analyzed data from the fourth survey (2015-2016) of the Research on Osteoarthritis/Osteoporosis Against Disability project, encompassing 2146 community residents from Japan's mountainous and coastal regions. A total of 1755 participants (81.8% of the baseline population) underwent extensive data collection including lifestyle and health questionnaires, anthropometric measurements and brain magnetic resonance imaging. The imaging data were processed to examine correlations between total brain volume, gray matter volume (GMV), white matter volume (WMV), cerebrospinal fluid volume and participant age.
Analysis showed significant sex differences in total brain volume, with GMV demonstrating a strong negative correlation with age - more pronounced than the moderate negative correlation seen in WMV. Cerebrospinal fluid volume exhibited a strong positive correlation with age. Notably, specific brain regions such as the bilateral amygdala, hippocampus, thalamus and primary motor cortex showed significant age-related volume reductions.
This study confirms that GMV and WMV are smaller in older individuals in the Japanese population, with more pronounced differences in GMV. The amygdala, hippocampus, thalamus and primary motor cortex were particularly affected. Geriatr Gerontol Int 2025; 25: 279-286.
本研究旨在调查衰老对日本社区居民脑容量的影响，重点关注随时间的变化趋势以及特定脑结构。
我们分析了骨关节炎/骨质疏松症抗残疾研究项目第四次调查（2015 - 2016年）的数据，该项目涵盖了来自日本山区和沿海地区的2146名社区居民。共有1755名参与者（占基线人群的81.8%）接受了广泛的数据收集，包括生活方式和健康问卷、人体测量以及脑磁共振成像。对成像数据进行处理，以检查全脑容量、灰质体积（GMV）、白质体积（WMV）、脑脊液体积与参与者年龄之间的相关性。
分析显示全脑容量存在显著的性别差异，GMV与年龄呈强负相关，比WMV中观察到的中度负相关更为明显。脑脊液体积与年龄呈强正相关。值得注意的是，双侧杏仁核、海马体、丘脑和初级运动皮层等特定脑区显示出与年龄相关的显著体积减少。
本研究证实，日本人群中老年人的GMV和WMV较小，GMV的差异更为明显。杏仁核、海马体、丘脑和初级运动皮层受到的影响尤为显著。《老年医学与老年病学国际杂志》2025年；25: 279 - 286。
