脂肪酶介导的硫基化学战剂的氧化中和：从间歇式反应器到连续流反应器
Oxidative Neutralisation of Sulfur-Based Chemical Warfare Agents Mediated by a Lipase: From Batch to Flow Reactor.
作者信息
Boddaert Maxime, Baptista da Silva Valmir, Mansour Sergui, Vuluga Daniela, Renard Pierre-Yves, Monbaliu Jean-Christophe M, Legros Julien
机构信息
Univ Rouen Normandie, INSA Rouen Normandie, CNRS, Normandie Univ, CARMeN UMR 6064, F-76000, Rouen, France.
Center for Integrated Technology and Organic Synthesis, MolSys Research Unit, University of Liège, B-4000, Liège (Sart Tilman), Belgium.
出版信息
Chemistry. 2025 Apr 1;31(19):e202403701. doi: 10.1002/chem.202403701. Epub 2025 Mar 12.
The sulfur-containing chemical warfare agents sulfur mustard HD and nerve agent VX are highly toxic and persistent in the environment. Therefore, their neutralisation requires harsh oxidation conditions, but also precise selectivity. Here we report the safe and effective detoxification of surrogates CEES and PhX by selective oxidation of the sulfur atom by generating peracetic acid from AcOEt and aq. HO assisted by the supported lipase CALB. Morever, it is possible to perform these neutralisations with safe 'on demand' generation of AcOOH in a flow system by using a packed bed reactor containing the supported biocatalyst.
含硫化学战剂芥子气（HD）和神经毒剂VX毒性极强且在环境中持久存在。因此，对它们进行中和需要苛刻的氧化条件，但同时也需要精确的选择性。在此，我们报告了通过负载型脂肪酶CALB辅助，由乙酸乙酯（AcOEt）和水溶液中的过氧化氢（aq. HO）生成过氧乙酸，对替代物2-氯乙基乙基硫醚（CEES）和苯基硫醚（PhX）进行硫原子选择性氧化，从而实现安全有效的解毒。此外，通过使用装有负载型生物催化剂的填充床反应器，在流动体系中以安全的“按需”方式生成过氧乙酸（AcOOH），就可以进行这些中和反应。
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