Lee Jiyoung, Kim Dayoung, Cha Sun Joo, Lee Jang-Won, Lee Eun-Young, Kim Hyung-Jun, Kim Kiyoung
Department of Medical Science, Soonchunhyang University, Asan 31538, Korea.
Department of Medical Biotechnology, Soonchunhyang University, Asan 31538, Korea.
BMB Rep. 2025 Apr;58(4):169-174. doi: 10.5483/BMBRep.2024-0047.
Tau, a microtubule-associated protein, is known for its significant involvement in neurodegenerative diseases. While various molecular and immunohistochemical techniques have confirmed the presence of Tau in podocytes, its precise function within these cells remains elusive. In this study, we investigate the role of Tau in kidney podocytes using Drosophila pericardial nephrocytes as a model. We found that knockdown of Drosophila Tau in nephrocytes resulted in apoptotic cell death and the disruption of nephrocyte structure. Furthermore, we observed that decreased Tau levels induced genomic damage and abnormal distribution of γ-H2Av, altering nuclei architecture in nephrocytes, and affecting the nuclear membrane structure by interfering with lamin with aging. Additionally, Tau knockdown led to a reduction in lipid droplets in Drosophila fat body tissues, suggesting a potential role of Tau in inter-organ communication. These findings underscore the importance of Tau in the nephrocytes of Drosophila, and advocate further research to broaden our understanding of podocyte biology in kidney diseases. [BMB Reports 2025; 58(4): 169-174].
tau蛋白是一种微管相关蛋白，因其在神经退行性疾病中的重要作用而闻名。虽然各种分子和免疫组织化学技术已证实足细胞中存在tau蛋白，但其在这些细胞中的精确功能仍不清楚。在本研究中，我们以果蝇心包肾细胞为模型，研究tau蛋白在肾足细胞中的作用。我们发现，果蝇肾细胞中tau蛋白的敲低导致细胞凋亡和肾细胞结构破坏。此外，我们观察到tau蛋白水平降低会导致基因组损伤和γ-H2Av异常分布，改变肾细胞核结构，并随着衰老通过干扰核纤层蛋白影响核膜结构。此外，tau蛋白敲低导致果蝇脂肪体组织中脂滴减少，提示tau蛋白在器官间通讯中可能发挥作用。这些发现强调了tau蛋白在果蝇肾细胞中的重要性，并提倡进一步研究以拓宽我们对肾脏疾病中足细胞生物学的理解。[《BMB报告》2025年；58(4):169 - 174]
