Goldberg J W, Lidsky M D
South Med J. 1985 Feb;78(2):222-3. doi: 10.1097/00007611-198502000-00034.
Cyclophosphamide, a potent alkylating agent, is effective therapy for some rheumatic diseases. Despite primary hepatic activation of the drug, hepatic toxicity has been reported only in one case. We have reported two episodes of hepatic dysfunction associated with oral cyclophosphamide administration in patients with systemic rheumatic diseases.
环磷酰胺是一种强效烷化剂，对某些风湿性疾病是有效的治疗药物。尽管该药主要在肝脏激活，但仅报道过1例肝毒性病例。我们报告了2例系统性风湿性疾病患者口服环磷酰胺后出现肝功能障碍的情况。
