Milford D V, Butler N, Clarke R, Vaid J
Department of Nephrology, Children's Hospital, Birmingham, UK.
Eur J Pediatr. 1995 May;154(5):411-2. doi: 10.1007/BF02072117.
A 5.5-year-old child with nephrotic syndrome was treated with cyclophosphamide. After 9 weeks of therapy she developed jaundice and abnormal liver function tests. No infective aetiology was found and the abnormal liver function tests resolved within 5 weeks of discontinuing cyclophosphamide. Cyclophosphamide has rarely been reported to cause liver dysfunction, but not in children treated for nephrotic syndrome, and paediatricians should therefore be aware of its potential for inducing reversible hepatic dysfunction.
一名5.5岁的肾病综合征患儿接受了环磷酰胺治疗。治疗9周后，她出现了黄疸和肝功能检查异常。未发现感染性病因，在停用环磷酰胺5周内，肝功能检查异常得到缓解。环磷酰胺导致肝功能障碍的报道很少，但在接受肾病综合征治疗的儿童中尚未有过报道，因此儿科医生应意识到其诱发可逆性肝功能障碍的可能性。
