Cyclopenta[]benzopyran Derivatives and Limonoids from with Cytotoxic and Anti-DENV Activity.

Eighteen cyclopenta[]benzopyran derivatives (- and -) and 10 limonoids (- and -) were identified from , including 10 undescribed compounds (-), all of which were identified by analysis of spectroscopic data, electronic circular dichroism calculations, and X-ray crystallography studies. Nine compounds displayed significant cytotoxic activity against three cancer cells, with IC values of 3-900 nM. Sixteen compounds demonstrated potent antiviral activity on the dengue virus, with selectivity index values between 13.0 and 532.6. A mechanism of action investigation revealed that compound may function as an eIF4E activator, which could suppress the expression of the E protein, thereby conferring significant activity against the dengue virus.