Yi Ping, Qiu Jian-Fei, Yang Xiao-Meng, Chen Fei-Fei, Yang Jue, Liu Juan, Jin Jun, Qi Lian-Xin, Hao Xiao-Jiang, Wu Jia-Hong, Yuan Chun-Mao
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China.
Natural Products Research Center of Guizhou Province, Guiyang 550014, China.
J Nat Prod. 2025 Jan 24;88(1):119-132. doi: 10.1021/acs.jnatprod.4c01194. Epub 2025 Jan 5.
Eighteen cyclopenta[]benzopyran derivatives (- and -) and 10 limonoids (- and -) were identified from , including 10 undescribed compounds (-), all of which were identified by analysis of spectroscopic data, electronic circular dichroism calculations, and X-ray crystallography studies. Nine compounds displayed significant cytotoxic activity against three cancer cells, with IC values of 3-900 nM. Sixteen compounds demonstrated potent antiviral activity on the dengue virus, with selectivity index values between 13.0 and 532.6. A mechanism of action investigation revealed that compound may function as an eIF4E activator, which could suppress the expression of the E protein, thereby conferring significant activity against the dengue virus.
从[具体来源未给出]中鉴定出18种环戊并[]苯并吡喃衍生物（-和-）和10种类柠檬苦素（-和-），其中包括10种未描述的化合物（-），所有这些化合物均通过光谱数据分析、电子圆二色性计算和X射线晶体学研究进行鉴定。9种化合物对三种癌细胞显示出显著的细胞毒性活性，IC值为3 - 900 nM。16种化合物对登革病毒表现出强效抗病毒活性，选择性指数值在13.0至532.6之间。作用机制研究表明，化合物[具体化合物未给出]可能作为一种eIF4E激活剂发挥作用，这可能抑制E蛋白的表达，从而赋予对登革病毒的显著活性。
