Kumar Vijayalakshmi, Sundramoorthy Ashok K
Department of Chemistry (SFS), Madras Christian College, East Tambaram, Chennai, India.
Centre for Nanobiosensors, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 600017, India.
Mini Rev Med Chem. 2025;25(7):529-538. doi: 10.2174/0113895575359305241218113847.
In recent years, there has been a growing emphasis on the "back-to-nature" movement, which has brought biopolymers derived from natural sources into the spotlight. These biopolymers are gaining attention for their versatile surface-active properties, anti-adhesive capabilities, excellent biocompatibility, non-toxicity, biodegradability, and antimicrobial effectiveness against a wide range of oral microorganisms, including both bacteria and fungi. Researchers have been actively modifying these eco-friendly, nature-based biopolymers to enhance their interaction with surrounding cells and tissues, improving their performance in vivo. This has led to innovative applications in areas such as surface coatings, controlled drug delivery, tissue repair, and dental implant devices. These advancements hold the potential to pave the way for the development of novel drug delivery systems with enhanced therapeutic properties, ultimately supporting the creation of innovative formulations for clinical use. This review aims to provide an up-to-date overview of recent developments, explore potential future directions, and highlight the promising applications of nature-derived biopolymers in oral healthcare.
近年来，人们越来越重视“回归自然”运动，这使得源自天然来源的生物聚合物成为焦点。这些生物聚合物因其多功能的表面活性特性、抗粘附能力、出色的生物相容性、无毒性、可生物降解性以及对包括细菌和真菌在内的多种口腔微生物的抗菌效果而受到关注。研究人员一直在积极修饰这些环保的、基于天然的生物聚合物，以增强它们与周围细胞和组织的相互作用，提高它们在体内的性能。这导致了在表面涂层、控释药物递送、组织修复和牙科植入装置等领域的创新应用。这些进展有可能为开发具有增强治疗特性的新型药物递送系统铺平道路，最终支持临床使用的创新制剂的创建。本综述旨在提供近期发展的最新概述，探索潜在的未来方向，并突出天然来源生物聚合物在口腔保健中的有前景的应用。
