Dauvermann Maria R, Costello Laura, Tronchin Giulia, Corley Emma, Holleran Laurena, Mothersill David, Rokita Karolina I, Kane Ruán, Hallahan Brian, McDonald Colm, Pasternak Ofer, Donohoe Gary, Cannon Dara M
Center for Neuroimaging, Cognition and Genomics (NICOG), Clinical Neuroimaging Laboratory, Galway Neuroscience Centre, University of Galway, Galway, Ireland.
Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Psychol Med. 2025 Jan 6;54(16):1-10. doi: 10.1017/S0033291724003064.
Childhood trauma (CT) is related to altered fractional anisotropy (FA) in individuals with schizophrenia (SZ). However, it remains unclear whether CT may influence specific cellular or extracellular compartments of FA in SZ with CT experience. We extended our previous study on FA in SZ (Costello et al., 2023) and examined the impact of CT on hypothesized lower free water-corrected FA (FA) and higher extracellular free water (FW).
Thirty-seven SZ and 129 healthy controls (HC) were grouped into the 'none/low' or 'high' CT group. All participants underwent diffusion-weighted magnetic resonance imaging. We performed tract-based spatial statistics to study the main effects of diagnostic group and CT, and the interaction between CT and diagnostic group across FA and FW.
SZ displayed lower FA within the corpus callosum and corona radiata compared to HC ( < 0.05, Threshold-Free Cluster Enhancement (TFCE)). Independent of diagnosis, we observed lower FA ( < 0.05, TFCE) and higher FW ( < 0.05, TFCE) in both SZ and HC with high CT levels compared to SZ and HC with none or low CT levels. Furthermore, we did not identify an interaction between CT and diagnostic group ( > 0.05, TFCE).
These novel findings suggest that the impact of CT on lower FA may reflect cellular rather than extracellular alterations in established schizophrenia. This highlights the impact of CT on white matter microstructure, regardless of diagnostic status.
童年创伤（CT）与精神分裂症（SZ）患者的分数各向异性（FA）改变有关。然而，尚不清楚CT是否会影响有CT经历的SZ患者FA的特定细胞或细胞外成分。我们扩展了之前关于SZ患者FA的研究（Costello等人，2023年），并研究了CT对假设的较低自由水校正FA（FA）和较高细胞外自由水（FW）的影响。
37名SZ患者和129名健康对照者（HC）被分为“无/低”或“高”CT组。所有参与者均接受了扩散加权磁共振成像。我们进行了基于束的空间统计，以研究诊断组和CT的主要影响，以及CT与诊断组在FA和FW上的相互作用。
与HC相比，SZ患者胼胝体和放射冠内的FA较低（<0.05，无阈值聚类增强（TFCE））。与无或低CT水平的SZ和HC相比，高CT水平的SZ和HC均观察到较低的FA（<0.05，TFCE）和较高的FW（<0.05，TFCE），与诊断无关。此外，我们未发现CT与诊断组之间存在相互作用（>0.05，TFCE）。
这些新发现表明，CT对较低FA的影响可能反映了已确诊精神分裂症患者的细胞而非细胞外改变。这突出了CT对白质微观结构的影响，无论诊断状态如何。
