Li Xin, Tao Liang, Zhong Meijuan, Wu Qian, Min Junjia, Wang Fudi
School of Pharmacy, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
College of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, Hunan Province, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Dec 25;53(6):747-755. doi: 10.3724/zdxbyxb-2024-0566.
As the central organ of metabolism, the liver plays a pivotal role in the regulation of the synthesis and metabolism of various nutrients within the body. Ferroptosis, as a newly discovered type of programmed cell death caused by the accumulation of iron-dependent lipid peroxides, is involved in the physiological and pathological processes of a variety of acute and chronic liver diseases. Ferroptosis can accelerate the pathogenetic process of acute liver injury, metabolic associated fatty liver disease, alcoholic liver disease, viral hepatitis, and autoimmune hepatitis; while it can slower disease progression in advanced liver fibrosis and hepatocellular carcinoma. This suggests that targeted regulation of ferroptosis may impact the occurrence and development of various liver diseases. This article reviews the latest research progress of ferroptosis in various liver diseases, including acute liver injury, metabolic associated fatty liver disease, alcoholic liver disease, viral hepatitis, autoimmune hepatitis, liver fibrosis and hepatocellular carcinoma. It aims to provide insights for the prevention and treatment of acute and chronic liver diseases through targeting ferroptosis.
作为新陈代谢的中心器官，肝脏在调节体内各种营养物质的合成与代谢方面发挥着关键作用。铁死亡是一种新发现的由铁依赖性脂质过氧化物积累引起的程序性细胞死亡类型，参与多种急慢性肝脏疾病的生理和病理过程。铁死亡可加速急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎和自身免疫性肝炎的发病进程；而在晚期肝纤维化和肝细胞癌中，它可减缓疾病进展。这表明对铁死亡进行靶向调控可能会影响各种肝脏疾病的发生发展。本文综述了铁死亡在各种肝脏疾病中的最新研究进展，包括急性肝损伤、代谢相关脂肪性肝病、酒精性肝病、病毒性肝炎、自身免疫性肝炎、肝纤维化和肝细胞癌。旨在通过靶向铁死亡为急慢性肝脏疾病的防治提供思路。
