The Fourth Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
The Fourth Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.
Biochimie. 2021 Jan;180:149-157. doi: 10.1016/j.biochi.2020.11.002. Epub 2020 Nov 6.
Regulated cell death (RCD) is a universal process in living organisms that is essential for tissue homeostasis or to the restoration of biological equilibrium following stress. Ferroptosis is a specific nonapoptotic cell death that is dependent on iron and is very different from other forms of RCD. Ferroptosis can affect the development of liver diseases such as drug-induced liver injury (DILI), liver fibrosis, and hepatocellular carcinoma (HCC) by regulating the level of intracellular iron, the production of intracellular reactive oxygen species, and lipid peroxides. In this review, we summarize the current knowledge of ferroptosis, in terms of discovery, history, characteristics, mechanism, and the factors regulating liver diseases. We discuss how these factors and signaling pathways change in the context of liver disease. Furthermore, we focus on delineating the roles of effective therapeutic drugs or compounds in liver disease. In summary, we discuss the role of ferroptosis in liver disease, providing a strategy and new ideas for preventing liver disease, finding new therapeutic targets, and reducing liver damage.
细胞程序性死亡（RCD）是一种普遍存在于生物体中的过程，对于组织稳态或在应激后恢复生物平衡至关重要。铁死亡是一种依赖于铁的特定非凋亡性细胞死亡，与其他形式的 RCD 有很大不同。铁死亡可以通过调节细胞内铁水平、细胞内活性氧和脂质过氧化物的产生来影响肝脏疾病的发展，如药物性肝损伤（DILI）、肝纤维化和肝细胞癌（HCC）。在这篇综述中，我们总结了铁死亡的最新知识，包括其发现、历史、特征、机制以及调节肝脏疾病的因素。我们讨论了这些因素和信号通路在肝脏疾病中的变化。此外，我们还重点阐述了有效治疗药物或化合物在肝脏疾病中的作用。总之，我们讨论了铁死亡在肝脏疾病中的作用，为预防肝脏疾病、寻找新的治疗靶点和减少肝损伤提供了策略和新的思路。
