对周细胞在脊髓损伤中作用的生理学见解
Physiological Insights Into the Role of Pericytes in Spinal Cord Injury.
作者信息
Jin Haiming, Rawlins Jessica, Chen Yiqi, Zheng Xiaohang, Charlesworth Oscar, Chen Junchun, Wang Gang, Luo Huoling, Cheng Wenxiang, Li Zhong Alan, Zhu Sipin, Xu Jiake
机构信息
Department of Orthopaedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
出版信息
J Cell Physiol. 2025 Jan;240(1):e31500. doi: 10.1002/jcp.31500.
Vascular regeneration plays a vital role in tissue repair yet is drastically impaired in those with a spinal cord injury (SCI). Pericytes are of great significance as they are entwined with vessel-specific endothelial cells and actively contribute to maintaining the spinal cord's vascular network. Within the neurovascular unit (NVU), subtypes of pericytes characterized by various markers such as PDGFR-β, Desmin, CD146, and NG-2 are involved in vascular regeneration in SCI repair. Various pericyte signaling, pericyte-derived exosomes, and endothelial-pericyte interplay were revealed to participate in SCI repair or fibrotic scars. Through further understanding pericyte biology, it is aimed to accurately generate subtypes of pericytes and develop their therapeutic potential. This review focuses on recent advanced research and development of pericytes as a potential treatment for SCI.
血管再生在组织修复中起着至关重要的作用，但在脊髓损伤（SCI）患者中却严重受损。周细胞具有重要意义，因为它们与血管特异性内皮细胞缠绕在一起，并积极参与维持脊髓的血管网络。在神经血管单元（NVU）中，以PDGFR-β、结蛋白、CD146和NG-2等各种标志物为特征的周细胞亚型参与了SCI修复中的血管再生。各种周细胞信号传导、周细胞衍生的外泌体以及内皮细胞与周细胞的相互作用被发现参与了SCI修复或纤维化瘢痕形成。通过进一步了解周细胞生物学，旨在准确地生成周细胞亚型并开发其治疗潜力。本综述重点关注周细胞作为SCI潜在治疗方法的最新前沿研究与进展。
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