Rehan Zahra, Brown-Maher Tracey
Memorial University of Newfoundland, St. John's, NL, Canada.
SAGE Open Med Case Rep. 2025 Jan 2;13:2050313X241307126. doi: 10.1177/2050313X241307126. eCollection 2025.
Erosive pustular dermatosis is a rare and chronic inflammatory condition of the scalp which can be mistaken for cutaneous malignancy, precancerous lesions, dermatitis or pyoderma gangrenosum. The recurrent and resistant characteristics of erosive pustular dermatosis of the scalp pose a challenge to successful management and remission of the condition. The purpose of this case report is to provide management options and treatment recommendations for refractory cases of erosive pustular dermatosis of the scalp. We report a case of erosive pustular dermatosis of the scalp that proved resistant to treatment, with various therapeutic modalities explored to address the persistent condition. In our patient, multiple treatment modalities included topical and oral corticosteroids, topical and oral antibiotics, topical vitamin D analogue, topical calcineurin inhibitor and oral isotretinoin. Based on our findings, refractory disease progression of erosive pustular dermatosis of the scalp may be more responsive to combination therapy rather than monotherapy.
糜烂性脓疱性皮肤病是一种罕见的头皮慢性炎症性疾病，可被误诊为皮肤恶性肿瘤、癌前病变、皮炎或坏疽性脓皮病。头皮糜烂性脓疱性皮肤病的复发和难治特性对该疾病的成功管理和缓解构成了挑战。本病例报告的目的是为头皮糜烂性脓疱性皮肤病的难治性病例提供管理方案和治疗建议。我们报告一例头皮糜烂性脓疱性皮肤病病例，该病例对治疗具有耐药性，我们探索了多种治疗方式来应对这种持续存在的病情。在我们的患者中，多种治疗方式包括外用和口服皮质类固醇、外用和口服抗生素、外用维生素D类似物、外用钙调神经磷酸酶抑制剂和口服异维A酸。根据我们的研究结果，头皮糜烂性脓疱性皮肤病的难治性疾病进展可能对联合治疗而非单一治疗更有反应。
