头皮糜烂性脓疱病的治疗：我们的经验及非传统局部药物的综述。
Treatment of erosive pustular dermatosis of the scalp: our experience and review of unconventional topical drugs.
机构信息
Department of Clinical and Experimental Medicine, Section of Dermatology, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy.
出版信息
Eur Rev Med Pharmacol Sci. 2023 Feb;27(3):1023-1026. doi: 10.26355/eurrev_202302_31197.
BACKGROUND
Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disorder of elderly individuals, characterized by relapsing pustular and eroded lesions of the scalp, which may lead to scarring alopecia. Treatment is challenging and classically based on topical and/or oral corticosteroids.
CASE REPORT
From 2008 to 2022, we treated fifteen cases of EPDS. We used mainly topical and systemic steroids with good results. Nevertheless, several non-steroidal topical drugs have been described in literature for the treatment of EPDS. We have carried out a brief review of these treatments.
CONCLUSIONS
Topical calcineurin inhibitors represent a valuable alternative to steroids to avoid skin atrophy. Emerging evidence about other topical treatments, such as calcipotriol, dapsone, zinc oxide, together with photodynamic therapy, are evaluated in our review.
背景
头皮侵蚀性脓疱病（EPDS）是一种罕见的老年人群炎症性疾病，表现为头皮反复发作的脓疱和糜烂性损害，可导致瘢痕性脱发。治疗具有挑战性，经典的治疗方法基于局部和/或口服皮质类固醇。
病例报告
从 2008 年到 2022 年，我们治疗了 15 例 EPDS 患者。我们主要使用局部和全身皮质类固醇治疗，效果良好。然而，文献中也描述了几种非甾体类局部药物治疗 EPDS。我们对这些治疗方法进行了简要回顾。
结论
局部钙调磷酸酶抑制剂是避免皮肤萎缩的皮质类固醇的一种有价值的替代药物。我们的综述评估了其他局部治疗方法的新证据，如钙泊三醇、达普松、氧化锌以及光动力疗法。
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