Wang Sheng-Min, Jung Younhea, Han Kyungdo, Ohn Kyoung, Park Hae-Young Lopilly, Park Chan Kee, Moon Jung Il
Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Department of Ophthalmology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Heliyon. 2024 Nov 21;11(1):e40617. doi: 10.1016/j.heliyon.2024.e40617. eCollection 2025 Jan 15.
We aimed to investigate the risk of developing depression in individuals with primary open-angle glaucoma with associated vision impairment.
We conducted a nationwide, population-based cohort study using data from the Korean National Health Information Database and National Disability Registry. We assessed baseline characteristics such as age, sex, income level, lifestyle factors, anthropometric data, lab results, and Charlson Comorbidity Index scores through diagnostic codes and health screening data. Depression risk in relation to glaucoma and vision impairment was analyzed using a multivariable-adjusted Cox proportional hazard model.
Among 3,680,570 individuals screened through the Korean National Health Screening Program in 2009, 681,515 were newly diagnosed with depression during follow-up. Subjects with glaucoma showed a higher risk of depression than those without glaucoma, with an adjusted hazard ratio (HR) of 2.011 (95 % confidence interval [CI]: 1.946-2.078) pre-adjustment and 1.085 (95 % CI: 1.050-1.121) post-adjustment for covariates. For those with glaucoma and vision impairment, the adjusted HR increased to 1.164 (95 % CI: 1.045-1.297) and to 1.207 (95 % CI: 1.039-1.403) with severe vision impairment. The association between glaucoma and depression was more pronounced in men (P for interaction = 0.001) and those with a Charlson Comorbidity Index <3 (P for interaction = 0.008).
Primary open-angle glaucoma increased the risk of developing depression. The risk escalated gradually with the presence and severity of concurrent vision impairment. The impact of glaucoma and vision impairment on new-onset depression was greater in men and in those with less comorbidities.
我们旨在调查伴有视力损害的原发性开角型青光眼患者发生抑郁症的风险。
我们利用韩国国家健康信息数据库和国家残疾登记处的数据进行了一项全国性的基于人群的队列研究。我们通过诊断编码和健康筛查数据评估了年龄、性别、收入水平、生活方式因素、人体测量数据、实验室检查结果和查尔森合并症指数评分等基线特征。使用多变量调整的Cox比例风险模型分析青光眼和视力损害相关的抑郁症风险。
在2009年通过韩国国家健康筛查计划筛查的3680570人中，681515人在随访期间被新诊断为抑郁症。青光眼患者发生抑郁症的风险高于无青光眼患者，调整前风险比（HR）为2.011（95%置信区间[CI]：1.946 - 2.078），调整协变量后为1.085（95% CI：1.050 - 1.121）。对于患有青光眼和视力损害的患者，调整后的HR增加到1.164（95% CI：1.045 - 1.297），重度视力损害患者增加到1.207（95% CI：1.039 - 1.403）。青光眼与抑郁症之间的关联在男性（交互作用P = 0.001）和查尔森合并症指数<3的患者中更为明显（交互作用P = 0.008）。
原发性开角型青光眼增加了发生抑郁症的风险。随着并发视力损害的出现和严重程度，风险逐渐升高。青光眼和视力损害对新发抑郁症的影响在男性和合并症较少的患者中更大。
