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A novel MXI1-NUTM2B fusion detected in an undifferentiated ovarian cancer.

作者信息

Elshafey Mohammed, Ghandour Malek, Adams Rebecca M, Neill Daniel, Gogoi Radhika

机构信息

Division of Gynecologic Oncology, Karmanos Cancer Institute, Wayne State University, 4100 John R St, Detroit, MI 48202, USA.

Department of Pathology, Karmanos Cancer Institute, Wayne State University, 4100 John R St, Detroit, MI 48202, USA.

出版信息

Gynecol Oncol Rep. 2024 Dec 6;57:101653. doi: 10.1016/j.gore.2024.101653. eCollection 2025 Feb.

DOI:10.1016/j.gore.2024.101653
PMID:39758708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11699607/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/11699607/360f92b86d5a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/11699607/0afe8a4e63b3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/11699607/360f92b86d5a/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/11699607/0afe8a4e63b3/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/21a9/11699607/360f92b86d5a/gr2.jpg

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本文引用的文献

1
Case report: NUT carcinoma with MXI1::NUTM1 fusion characterized by abdominopelvic lesions and ovarian masses in a middle-aged female.病例报告：以一名中年女性腹盆腔病变和卵巢肿块为特征的伴有MXI1::NUTM1融合的NUT癌。
Front Oncol. 2023 Jan 11;12:1091877. doi: 10.3389/fonc.2022.1091877. eCollection 2022.
2
NUT Carcinoma: Clinicopathologic Features, Molecular Genetics and Epigenetics.NUT癌：临床病理特征、分子遗传学与表观遗传学
Front Oncol. 2022 Mar 16;12:860830. doi: 10.3389/fonc.2022.860830. eCollection 2022.
3
Immunotherapy and Targeting the Tumor Microenvironment: Current Place and New Insights in Primary Pulmonary NUT Carcinoma.
免疫疗法与肿瘤微环境靶向治疗：原发性肺NUT癌的现状与新见解
Front Oncol. 2021 Sep 30;11:690115. doi: 10.3389/fonc.2021.690115. eCollection 2021.
4
NUT Carcinoma in the Pelvic Cavity With Unusual Pathologic Features.盆腔 NUT 癌伴不典型病理特征。
Int J Gynecol Pathol. 2022 May 1;41(3):292-297. doi: 10.1097/PGP.0000000000000801. Epub 2021 Jun 23.
5
Primary renal NUT carcinoma identified by next-generation sequencing: a case report and literature review.通过二代测序鉴定的原发性肾NUT癌：一例病例报告及文献综述
Int J Clin Exp Pathol. 2021 May 15;14(5):662-669. eCollection 2021.
6
Supercharging BRD4 with NUT in carcinoma.BRD4 在癌中的 NUT 超驱动。
Oncogene. 2021 Feb;40(8):1396-1408. doi: 10.1038/s41388-020-01625-0. Epub 2021 Jan 15.
7
A MXI1-NUTM1 fusion protein with MYC-like activity suggests a novel oncogenic mechanism in a subset of NUTM1-rearranged tumors.一种具有 MYC 样活性的 MXI1-NUTM1 融合蛋白提示了一组 NUTM1 重排肿瘤中的新型致癌机制。
Lab Invest. 2021 Jan;101(1):26-37. doi: 10.1038/s41374-020-00484-3. Epub 2020 Sep 1.
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Phase 1 Study of Molibresib (GSK525762), a Bromodomain and Extra-Terminal Domain Protein Inhibitor, in NUT Carcinoma and Other Solid Tumors.溴结构域和额外末端结构域蛋白抑制剂莫利西布（GSK525762）在NUT癌和其他实体瘤中的1期研究
JNCI Cancer Spectr. 2019 Nov 6;4(2):pkz093. doi: 10.1093/jncics/pkz093. eCollection 2020 Apr.
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