Yang Yue, Shi Jinjie, Yu Jiming, Zhao Xin, Zhu Ke, Wang Shen, Zhang Xinwen, Zhang Xieyu, Wei Guangcheng, Cao Wei
Rheumatology Department, Wangjing Hospital of China Academy of Chinese Medical Sciences, Beijing, People's Republic of China.
Graduate School, Beijing University of Chinese Medicine, Beijing, People's Republic of China.
J Inflamm Res. 2024 Dec 30;17:11845-11860. doi: 10.2147/JIR.S497240. eCollection 2024.
Lactic acid (LA) is an essential glycolytic metabolite and energy source in the body, which is present in high levels in the synovial fluid of patients with rheumatoid arthritis (RA) and is a reliable indicator for identifying inflammatory arthritis. LA not only acts as an inflammatory amplifier in RA, recent studies have found that novel posttranslational modification (PTM) lactylation mediated by LA may also play a key role in RA. Single-cell sequencing showed that the RA lactylation score of patients with RA was significantly increased, and core lactylation-promoting genes, including NDUFB3, NGLY1, and other genes, were found to be potential biomarkers of RA. More studies have shown that lactylation can regulate genes in various cells, such as fibroblast-like synoviocytes (FLSs) and macrophages, thus playing a special role in the development and occurrence of autoimmune diseases, neurological diseases, and cancer diseases. In this paper, we review the research on lactylation in RA-related cells and mechanisms and bring new insights into the pathogenesis, diagnosis, and treatment of RA.
乳酸（LA）是人体中一种重要的糖酵解代谢产物和能量来源，在类风湿关节炎（RA）患者的滑液中含量很高，是识别炎症性关节炎的可靠指标。LA不仅在RA中作为炎症放大器起作用，最近的研究发现，由LA介导的新型翻译后修饰（PTM）乳酸化也可能在RA中起关键作用。单细胞测序显示，RA患者的RA乳酸化评分显著增加，并且发现包括NDUFB3、NGLY1等基因在内的核心乳酸化促进基因是RA的潜在生物标志物。更多研究表明，乳酸化可以调节多种细胞中的基因，如成纤维样滑膜细胞（FLS）和巨噬细胞，从而在自身免疫性疾病、神经疾病和癌症疾病的发生发展中发挥特殊作用。在本文中，我们综述了RA相关细胞中乳酸化及其机制的研究，并为RA的发病机制、诊断和治疗带来了新的见解。
