Hilz Emily N, Gore Andrea C
The University of Texas, Austin, TX, USA.
Policy Insights Behav Brain Sci. 2023 Oct;10(2):142-150. doi: 10.1177/23727322231196794. Epub 2023 Oct 26.
Endocrine-disrupting chemicals (EDCs) are chemicals that disrupt the normal functioning of endocrine system hormones, leading to a range of adverse health effects in humans and wildlife. Exposure to EDCs is ubiquitous and occurs through contaminated food and water, air, consumer products, and transfer from parents to offspring. Effective regulation has been challenging due to a limited understanding of EDCs' complex and nonlinear dose-response relationships, as well as difficulty in attributing specific health effects to individual EDC exposures in real-world scenarios. Current EDC policies face limitations in terms of the diversity and complexity of EDCs, the lack of comprehensive testing requirements, and the need for more robust regulatory frameworks that consider cumulative and mixture effects of EDCs. Understanding these aspects is crucial for developing effective and evidence-based EDC policies that can safeguard public health and the environment.
内分泌干扰化学物质（EDCs）是指那些干扰内分泌系统激素正常功能的化学物质，会给人类和野生动物带来一系列不良健康影响。接触EDCs的情况普遍存在，可通过受污染的食物、水、空气、消费品以及从父母传给后代等途径发生。由于对EDCs复杂且非线性的剂量反应关系了解有限，以及在现实场景中难以将特定健康影响归因于个体EDC暴露，有效监管一直具有挑战性。当前的EDC政策在EDCs的多样性和复杂性、缺乏全面的测试要求以及需要更强大的监管框架以考虑EDCs的累积和混合效应等方面面临限制。了解这些方面对于制定能够保障公众健康和环境的有效且基于证据的EDC政策至关重要。
