Endocrine-Disrupting Chemicals: Science and Policy.

Endocrine-disrupting chemicals (EDCs) are chemicals that disrupt the normal functioning of endocrine system hormones, leading to a range of adverse health effects in humans and wildlife. Exposure to EDCs is ubiquitous and occurs through contaminated food and water, air, consumer products, and transfer from parents to offspring. Effective regulation has been challenging due to a limited understanding of EDCs' complex and nonlinear dose-response relationships, as well as difficulty in attributing specific health effects to individual EDC exposures in real-world scenarios. Current EDC policies face limitations in terms of the diversity and complexity of EDCs, the lack of comprehensive testing requirements, and the need for more robust regulatory frameworks that consider cumulative and mixture effects of EDCs. Understanding these aspects is crucial for developing effective and evidence-based EDC policies that can safeguard public health and the environment.