Setoyama Honami, Ota Shintaro, Yoshida Mayuko, Kawashima Shigetaka, Kusumoto-Yoshida Ikue, Kashiwadani Hideki, Kuwaki Tomoyuki
Department of Physiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
iScience. 2024 Oct 18;27(11):111197. doi: 10.1016/j.isci.2024.111197. eCollection 2024 Nov 15.
Positive affect promotes mental health and physical well-being, which may involve modifications in the autonomic nervous system activity. Here, we examine, using chemogenetic techniques, the effects of nucleus accumbens (NAc) activation on affect and body temperature regulation as a proxy of autonomic function. A conditioned place preference test revealed that nucleus accumbens activation induced positive affect. Chemogenetic and natural activations inhibited intruder stress-induced hyperthermia and prostaglandin E-induced fever. Chemogenetic inhibition did not show a negative affect but canceled the positive affect induced by the natural stimulus of chocolate or sucrose. Counting of c-Fos expression confirmed chemogenetic and sucrose-induced activation of the NAc. Our findings indicate that nucleus accumbens activation modifies a component of autonomic nervous activity and that this mechanism may underscore the link between positive affect and physical well-being. Applying our observations to humans may reduce fever side reactions of vaccines by employing preventive treatments that induce positive affect.
积极情绪促进心理健康和身体健康，这可能涉及自主神经系统活动的改变。在此，我们使用化学遗传学技术研究伏隔核（NAc）激活对情绪和体温调节的影响，以此作为自主功能的一个指标。条件性位置偏好测试显示，伏隔核激活会诱发积极情绪。化学遗传学激活和自然激活均抑制入侵者应激诱导的体温过高以及前列腺素E诱导的发热。化学遗传学抑制并未显示出消极情绪，但消除了巧克力或蔗糖自然刺激所诱发的积极情绪。对c-Fos表达的计数证实了化学遗传学和蔗糖诱导的伏隔核激活。我们的研究结果表明，伏隔核激活会改变自主神经活动的一个组成部分，并且这一机制可能是积极情绪与身体健康之间联系的基础。将我们的观察结果应用于人类，或许可以通过采用诱导积极情绪的预防性治疗来减少疫苗的发热副作用。
