Kang Xia, Zhao Kun, Huang Zhu, Fukada So-Ichiro, Qi Xiao-Wei, Miao Hongming
Department of Pathophysiology, College of High Altitude Military Medicine, Army Medical University, Chongqing 400038, China.
Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu, Sichuan 610000, China.
Genes Dis. 2024 Mar 9;12(2):101264. doi: 10.1016/j.gendis.2024.101264. eCollection 2025 Mar.
Pdgfrα stromal cells are a group of cells specifically expressing Pdgfrα, which may be mentioned with distinct names in different tissues. Importantly, the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties, show complex functions in regulating the microenvironment, and are critical to tissue regeneration, repair, and degeneration. Comparing the similarities and differences between distinct tissue-resident Pdgfrα stromal cells is helpful for us to more comprehensively and deeply understand the behaviors of these cells and to explore some common regulating mechanisms and therapeutical targets. In this review, we summarize previous and current findings on Pdgfrα stromal cells in various tissues and discuss the crosstalk between Pdgfrα stromal cells and microenvironment.
血小板衍生生长因子受体α（Pdgfrα）基质细胞是一组特异性表达Pdgfrα的细胞，在不同组织中可能有不同的名称。重要的是，众多研究结果表明，这些细胞具有完全相似的生物标志物和特性，在调节微环境中发挥复杂功能，对组织再生、修复和退变至关重要。比较不同组织驻留的Pdgfrα基质细胞之间的异同，有助于我们更全面、深入地了解这些细胞的行为，并探索一些共同的调节机制和治疗靶点。在本综述中，我们总结了以往及当前关于不同组织中Pdgfrα基质细胞的研究结果，并讨论了Pdgfrα基质细胞与微环境之间的相互作用。
