Zhang Ying, Li Lijuan, Guo Yunsong
Endocrinology Department, The People's Hospital of Yubei District of Chongqing city, Chongqing 401120, China.
Medical Department, Chongqing Hospital of Traditional Chinese Medicine, Chongqing 400021, China.
Iran J Public Health. 2024 Dec;53(12):2613-2624.
Salivary compounds can be used as diagnostic markers for changes in the oral cavity that cause oral problems in type 2 diabetes mellitus (T2DM).
This meta-analysis searched PubMed/Medline, EMBASE, Scopus and Cochrane Library, and the Web of Science until Nov 2023. The observational studies included patients with T2DM and healthy controls aged > 18 yr with no oral health problems or systematic or periodontal diseases. The Quality in Prognostic Studies (QUIPS) tool was used to evaluate the risk of bias. The random-effects model was constructed using standardized mean differences (SMD).
The meta-analysis analyzed 13 observational studies that included 519 patients with T2DM and 356 healthy controls. Non-fasting periods of 30 min to 8 h were used to measure salivary profiles. Overall, salivary proinflammatory mediators favored patients with T2DM (SMD: 1.66; CI: 0.42, 2.91, <0.01) compared with healthy subjects. Subgroup analysis revealed that interleukin-6 (SMD: 1.33; CI: -0.04, 2.69, <0.05), followed by interleukin-8 (SMD: 0.92; CI: -0.71, 2.55, <0.13), was greater in patients with T2DM than in healthy subjects. Among patients with T2DM, network analysis identified salivary factors most closely associated with male sex (i.e., tumor necrosis factor), female sex (i.e., interleukin-8), fasting plasma glucose (i.e., C-reactive protein), HbA1c (i.e., IL-8), and age (i.e., C-reactive protein).
Overall, salivary IL-6 levels were greater in patients with T2DM and might be considered for monitoring oral changes. Moreover, network analysis could identify different salivary components that were most closely associated with patient characteristics.
唾液化合物可作为2型糖尿病（T2DM）患者口腔变化导致口腔问题的诊断标志物。
本荟萃分析检索了截至2023年11月的PubMed/Medline、EMBASE、Scopus和Cochrane图书馆以及Web of Science。纳入的观察性研究包括年龄>18岁、无口腔健康问题或系统性或牙周疾病的T2DM患者和健康对照。采用预后研究质量（QUIPS）工具评估偏倚风险。使用标准化均值差（SMD）构建随机效应模型。
该荟萃分析纳入了13项观察性研究，共519例T2DM患者和356例健康对照。采用30分钟至8小时的非空腹时段测量唾液指标。总体而言，与健康受试者相比，T2DM患者的唾液促炎介质水平更高（SMD：1.66；CI：0.42，2.91，<0.01）。亚组分析显示，T2DM患者的白细胞介素-6（SMD：1.33；CI：-0.04，2.69，<0.05）水平高于健康受试者，其次是白细胞介素-8（SMD：0.92；CI：-0.71，2.55，<0.13）。在T2DM患者中，网络分析确定了与男性（即肿瘤坏死因子）、女性（即白细胞介素-8）、空腹血糖（即C反应蛋白）、糖化血红蛋白（即IL-8）和年龄（即C反应蛋白）密切相关的唾液因子。
总体而言，T2DM患者的唾液白细胞介素-6水平较高，可考虑用于监测口腔变化。此外，网络分析可以识别与患者特征密切相关的不同唾液成分。
