醋酸钙和醋酸镁对Wistar大鼠致癌剂量氯化镉组织分布的影响。
Effects of calcium and magnesium acetates on tissue distribution of carcinogenic doses of cadmium chloride in Wistar rats.
作者信息
Kasprzak K S, Poirier L A
出版信息
Toxicology. 1985 Mar 15;34(3):221-30. doi: 10.1016/0300-483x(85)90173-8.
Previous studies have shown that magnesium, unlike calcium, prevents cadmium carcinogenesis at the subcutaneous injection site, and that neither magnesium nor calcium has any significant influence on the production of testicular tumors by cadmium in rats. The present investigation attempts to disclose the nature of those different effects by comparing the results of administration of both physiological metals on the uptake and distribution of carcinogenic doses of cadmium in rats. Male Wistar rats received a single subcutaneous (s.c.) injection of 109CdCl2 (0.02 mmol/kg or 0.04 mmol/kg) and s.c. injections (one daily) of calcium acetate (CaAcet; 0.16 mmol/kg), or magnesium acetate (MgAcet; 4 mmol/kg), or saline on the day before, the day of and the day after the 109CdCl2 dosing. The concentration of cadmium in tissues was determined by gamma-counting on the 4th, the 15th and the 45th day after the 109CdCl2 injection. The concentration of cadmium in tissues on day 4 was ranked as follows: liver greater than kidney greater than the injection site skin greater than pancreas greater than spleen greater than heart greater than lung greater than distant skin greater than testes greater than blood. Administration of CaAcet increased by over 20% and that of MgAcet decreased by over 30% the initial uptake of both cadmium doses at the injection site. Thus MgAcet may prevent cadmium carcinogenesis by inhibiting the uptake of cadmium by the injection site tissues. In the testis and in all other tissues investigated, except kidney, the effects of the physiological metals were reversed, CaAcet tended to decrease and MgAcet tended to increase the uptake of cadmium. CaAcet and MgAcet exerted no noticeable effects on the uptake of cadmium by the kidney. The observed results of CaAcet and MgAcet administration on the concentration of cadmium in distal tissues seem to depend on the alterations in cadmium uptake at the injection site.
以往的研究表明，与钙不同，镁可预防皮下注射部位的镉致癌作用，并且镁和钙对大鼠镉诱导的睾丸肿瘤生成均无显著影响。本研究试图通过比较这两种生理金属给药后对大鼠致癌剂量镉的摄取和分布的影响结果，来揭示这些不同效应的本质。雄性Wistar大鼠单次皮下注射109CdCl2（0.02 mmol/kg或0.04 mmol/kg），并在注射109CdCl2前一天、当天及之后一天每天皮下注射醋酸钙（CaAcet；0.16 mmol/kg）、醋酸镁（MgAcet；4 mmol/kg）或生理盐水。在注射109CdCl2后的第4天、第15天和第45天，通过γ计数法测定组织中的镉浓度。第4天时组织中镉浓度的排序如下：肝脏＞肾脏＞注射部位皮肤＞胰腺＞脾脏＞心脏＞肺＞远离注射部位的皮肤＞睾丸＞血液。给予CaAcet使两个镉剂量在注射部位的初始摄取量增加了20%以上，而给予MgAcet使初始摄取量减少了30%以上。因此，MgAcet可能通过抑制注射部位组织对镉的摄取来预防镉致癌作用。在睾丸以及除肾脏外的所有其他研究组织中，生理金属的作用相反，CaAcet倾向于降低镉的摄取，而MgAcet倾向于增加镉的摄取。CaAcet和MgAcet对肾脏摄取镉没有明显影响。观察到的给予CaAcet和MgAcet后远端组织中镉浓度的结果似乎取决于注射部位镉摄取的变化。
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