Müller L, Abel J, Ohnesorge F K
Toxicology. 1986 May;39(2):187-95. doi: 10.1016/0300-483x(86)90135-6.
Male Wistar rats received by gavage saline or about 25 micrograms cadmium (Cd)/kg/day as Cd-acetate (Cd-Ac), Cd-metallothionein (Cd-MT) or Cd-glutathione (Cd-GSH) 5 times per week for 28 times. At all treatments 0.2-0.3% of the totally administered Cd dose was found in liver, kidneys, small intestine and pancreas, whereas none of the Cd forms applied resulted in a Cd accumulation in testes. Cd in small intestine was not increased by Cd-MT. However, it was raised by Cd-Ac and even more by Cd-GSH. A smaller increase in hepatic and renal Cd resulted from Cd-GSH than from Cd-Ac or Cd-MT. Cd in pancreas increased after Cd-GSH but not after Cd-Ac or Cd-MT. Copper (Cu) rose in small intestine and testes but decreased in kidneys independent of either Cd treatment. Concomitantly, zinc (Zn) was decreased in small intestine and testes. The tissue concentration of metallothionein (MT) was only marginally increased by all treatments. The highest value (80%) above controls) was found in small intestine after Cd-GSH. Intestinal Cd as well as testicular Cu were related to the tissue MT. Therefore, the distribution of Cd between various organs depends on the Cd form applied. There is some relationship to the distribution of Cu and Zn.
雄性Wistar大鼠每周经口灌胃给予生理盐水或约25微克镉（Cd）/千克/天的醋酸镉（Cd-Ac）、镉-金属硫蛋白（Cd-MT）或镉-谷胱甘肽（Cd-GSH），共给药28次。在所有处理组中，肝脏、肾脏、小肠和胰腺中发现的镉剂量占总给药量的0.2-0.3%，而所应用的任何一种镉形式均未导致睾丸中镉的蓄积。小肠中的镉含量未因Cd-MT而增加。然而，Cd-Ac使其升高，Cd-GSH使其升高得更多。与Cd-Ac或Cd-MT相比，Cd-GSH导致肝脏和肾脏中镉的增加幅度较小。Cd-GSH处理后胰腺中的镉增加，而Cd-Ac或Cd-MT处理后未增加。无论哪种镉处理，小肠和睾丸中的铜（Cu）升高，而肾脏中的铜降低。同时，小肠和睾丸中的锌（Zn）降低。所有处理组中金属硫蛋白（MT）的组织浓度仅略有增加。Cd-GSH处理后小肠中的MT含量最高（比对照组高80%）。小肠中的镉以及睾丸中的铜与组织MT有关。因此，不同器官中镉的分布取决于所应用的镉形式。这与铜和锌的分布存在一定关系。
