Irazabal Nadia Inés, Urrestarazu Elena, Valencia Miguel, Manzanilla Oscar, Crespo-Eguilaz Nerea, Isaguirre María Belén, Sánchez-Carpintero Rocío
Paediatric Neurology Unit. Department of Paediatrics. Clinica Universidad de Navarra, Pamplona, Spain.
Department of Clinical Neurophysiology. Clinica Universidad de Navarra, Pamplona, Spain.
Heliyon. 2024 Nov 23;10(24):e40599. doi: 10.1016/j.heliyon.2024.e40599. eCollection 2024 Dec 30.
To describe the features of cortical oscillatory activity and neuronal synchronization by monitoring responses evoked by chirp-modulated tone (CMT) and look for relationships with cognition in healthy children.
We recruited 23 healthy children, 1-18 years old, assessed their cognitive abilities and recorded the cortical oscillatory activity evoked by CMTs. We obtained descriptive statistics and looked for correlations with cognitive abilities.
In the low gamma band, the neuronal synchronization evoked by CMTs increased with age, reaching adult features by 12 years of age (rho = 0.5; p = 0.042). In the high gamma band, neuronal recruitment was greater at younger ages (rho = -0.55; p = 0.029). In four of the six under-6-year-old participants, there was no CMT-evoked response. We found that the greater a child's receptive vocabulary skills, the lower the frequency at which maximal neuronal recruitment occurred (rho = -0.65; p = 0.003).
CMT-evoked cortical oscillatory activity is affected by degree of brain maturation and could be a potential biomarker of language-related disability. Our description of the cortical responses evoked by CMTs in healthy children is a step towards recognition of abnormal patterns and the possible use of this approach as a biomarker of brain disorders in children.
通过监测线性调频调谐音（CMT）诱发的反应来描述皮质振荡活动和神经元同步的特征，并寻找其与健康儿童认知的关系。
我们招募了23名1至18岁的健康儿童，评估他们的认知能力，并记录CMT诱发的皮质振荡活动。我们获得了描述性统计数据，并寻找与认知能力的相关性。
在低γ频段，CMT诱发的神经元同步随年龄增长而增加，到12岁时达到成人特征（rho = 0.5；p = 0.042）。在高γ频段，神经元募集在较年轻年龄段更为明显（rho = -0.55；p = 0.029）。在6岁以下的6名参与者中，有4名没有CMT诱发的反应。我们发现，儿童的接受性词汇技能越强，最大神经元募集发生的频率越低（rho = -0.65；p = 0.003）。
CMT诱发的皮质振荡活动受大脑成熟程度的影响，可能是与语言相关残疾的潜在生物标志物。我们对健康儿童中CMT诱发的皮质反应的描述是朝着识别异常模式以及将这种方法用作儿童脑部疾病生物标志物迈出的一步。
