Zhang Zhiwei, Yang Qianwen, He Panpan, Liu Xiaoming, Zeng Xuejiao, Mao Xueqian, Jin Xueyi, Hu Ying, Jing Lipeng
Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu Province, China.
Heliyon. 2024 Oct 11;10(24):e39322. doi: 10.1016/j.heliyon.2024.e39322. eCollection 2024 Dec 30.
There has been a growing body of research demonstrating that thigh circumference is closely associated with the development of various chronic disease. However, limited evidence has been obtained regarding the relationship between thigh circumference and sarcopenia.
The aim of this study was to investigate the relationship between thigh circumference and sarcopenia, and explore the potential role of thigh circumference for sarcopenia screening among community-dwelling older adults.
The investigation was carried out in six rural communities located in northwestern China with participants aged ≥60 years old. We collected variables related to sarcopenia, including function, muscle mass, and strength. The thigh circumference was categorized into four groups based on quartiles, with the first quartile (≤46.65 cm); the second quartile (46.66-48.50 cm); the third quartile (48.51-50.55 cm); and the fourth quartile (>50.55 cm). The associations and screening effect were estimated with multivariate logistics regression and ROC curves.
Of the 1000 participants aged 70.72 ± 4.68 years. Compared with the first quartile (≤46.65 cm), the odds ratios for the second, third, and fourth quartiles of thigh circumference were 0.465 (95%CI: 0.281-0.770, p = 0.003), 0.199 (95%CI: 0.097-0.407, p < 0.001), and 0.059 (95%CI: 0.016-0.220, p < 0.001), respectively. The regression results were consistent across different sexes. The AUC and cutoff values of thigh circumference for sarcopenia were 0.873 (95 % CI 0.836-0.909, p < 0.001) and 48.83 cm for men and 0.861 (95 % CI 0.822-0.900, p < 0.001) and 46.78 cm for women. There was a positive correlation between thigh circumference and skeletal muscle mass (r = 0.747, p < 0.001), hand grip strength (r = 0.337, p < 0.001), and gait speed (r = 0.142, p < 0.001), while a negative correlation was observed with five-times-sit-to-stand test (r = -0.073, p = 0.021).
There was a negative correlation between thigh circumference and sarcopenia, suggesting that thigh circumference may serve as a potential useful indicator for sarcopenia screening in the elderly.
越来越多的研究表明，大腿围与多种慢性疾病的发生密切相关。然而，关于大腿围与肌肉减少症之间的关系，目前获得的证据有限。
本研究旨在探讨大腿围与肌肉减少症之间的关系，并探讨大腿围在社区居住老年人肌肉减少症筛查中的潜在作用。
在中国西北部的六个农村社区对年龄≥60岁的参与者进行调查。我们收集了与肌肉减少症相关的变量，包括功能、肌肉质量和力量。根据四分位数将大腿围分为四组，第一四分位数（≤46.65厘米）；第二四分位数（46.66 - 48.50厘米）；第三四分位数（48.51 - 50.55厘米）；第四四分位数（>50.55厘米）。通过多因素逻辑回归和ROC曲线估计相关性和筛查效果。
1000名参与者的年龄为70.72±4.68岁。与第一四分位数（≤46.65厘米）相比，大腿围第二、第三和第四四分位数的优势比分别为0.465（95%CI：0.281 - 0.770，p = 0.003）、0.199（95%CI：0.097 - 0.407，p < 0.001）和0.059（95%CI：0.016 - 0.220，p < 0.001）。不同性别间回归结果一致。男性肌肉减少症的大腿围AUC和截断值分别为0.873（95%CI 0.836 - 0.909，p < 0.001）和48.83厘米，女性为0.861（95%CI 0.822 - 0.900，p < 0.001）和46.78厘米。大腿围与骨骼肌质量（r = 0.747，p < 0.001）、握力（r = 0.337，p < 0.001）和步速（r = 0.142，p < 0.001）呈正相关，而与五次坐立试验呈负相关（r = -0.073，p = 0.021）。
大腿围与肌肉减少症呈负相关，提示大腿围可能作为老年人肌肉减少症筛查的潜在有用指标。
