Breiter N, Ungemach F R, Beck G, Hegner D, Mayr A
Strahlentherapie. 1985 Mar;161(3):168-76.
A significant reduction of mortality after lethal irradiation (7,8 and 9 Gy X-ray total-body irradiation) was achieved by continuous therapeutic subcutaneous application of the biologic inducers PIND-AVI and PIND-ORF. This was obtained by a stimulation of the investigated spleen parameters and a stimulation of leucocytes and phagocytosis. The inducers had no significant influence on the radiogenic reduction of blood cells and bone marrow cells, of the relative spleen and thymus weight and of the DNA and protein level of spleen and thymus. The regeneration of blood leucocytes (preponderantly by PIND-AVI) and of the spleen (preponderantly by PIND-ORF) was accelerated, but not the thymus regeneration which was already rather low. The leucocyte phagocytosis which increased generally after irradiation was markedly stimulated by paramunization. This stimulation was also observed after a latent time in animals submitted to sham irradiation. Its temporal appearance and its quantitative and qualitative properties corresponded to the effects of inducers after X-ray irradiation. Both inducers were found to be harmless in all experiments.
通过皮下持续治疗应用生物诱导剂PIND - AVI和PIND - ORF，可显著降低致死性辐射（7、8和9 Gy X射线全身照射）后的死亡率。这是通过刺激所研究的脾脏参数以及刺激白细胞和吞噬作用实现的。诱导剂对血细胞和骨髓细胞的辐射性减少、相对脾脏和胸腺重量以及脾脏和胸腺的DNA和蛋白质水平均无显著影响。血液白细胞（主要由PIND - AVI）和脾脏（主要由PIND - ORF）的再生加速，但胸腺再生并未加速，其再生本来就很低。辐射后通常会增加的白细胞吞噬作用受到免疫增强的显著刺激。在接受假照射的动物经过一段潜伏期后也观察到了这种刺激。其出现时间及其定量和定性特性与X射线照射后诱导剂的作用相对应。在所有实验中均发现这两种诱导剂是无害的。
