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糖尿病酮症酸中毒中的哈曼综合征:揭示一种罕见且危及生命的并发症。

Hamman Syndrome in Diabetic Ketoacidosis: Unveiling a Rare and Life-Threatening Complication.

作者信息

Daher Bouchra, Kouhen Fadila, Afandi Oussama, Laidi Soukaina, Yassine Najiba

机构信息

Pulmonology, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.

Radiotherapy, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.

出版信息

Cureus. 2024 Dec 4;16(12):e75110. doi: 10.7759/cureus.75110. eCollection 2024 Dec.

DOI:10.7759/cureus.75110
PMID:39759658
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11698482/
Abstract

Hamman syndrome, or spontaneous pneumomediastinum, is a rare condition characterized by the presence of free air in the mediastinum, often triggered by increased intrathoracic pressure from vomiting, coughing, or intense physical exertion. Its association with diabetic ketoacidosis (DKA) is extremely uncommon. We report a case of an 18-year-old male with poorly controlled type 1 diabetes who developed DKA complicated by pneumomediastinum, subcutaneous emphysema, and a small pneumothorax. The condition was likely precipitated by Kussmaul's respiration and severe vomiting. After treatment for DKA with insulin and fluids, the patient improved, and follow-up imaging showed complete resolution of the pneumomediastinum. This case underscores the importance of recognizing and managing this rare complication in patients with DKA.

摘要

哈曼综合征,即自发性纵隔气肿,是一种罕见病症,其特征为纵隔内出现游离气体,通常由呕吐、咳嗽或剧烈体力活动导致的胸腔内压力升高所引发。它与糖尿病酮症酸中毒(DKA)的关联极为罕见。我们报告一例18岁1型糖尿病控制不佳的男性患者,该患者发生了DKA,并伴有纵隔气肿、皮下气肿和少量气胸。病情可能由库斯莫尔呼吸和严重呕吐诱发。在用胰岛素和液体治疗DKA后,患者病情好转,后续影像学检查显示纵隔气肿完全消退。该病例强调了识别和处理DKA患者中这种罕见并发症的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6967/11698482/bf217dde50d7/cureus-0016-00000075110-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6967/11698482/a7294a5213c6/cureus-0016-00000075110-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6967/11698482/bf217dde50d7/cureus-0016-00000075110-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6967/11698482/a7294a5213c6/cureus-0016-00000075110-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6967/11698482/bf217dde50d7/cureus-0016-00000075110-i02.jpg

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本文引用的文献

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An Uncommon Presentation of Hamman's Syndrome in an Adolescent With Acute Diabetic Ketoacidosis and Newly Diagnosed Type 1 Diabetes.一名患有急性糖尿病酮症酸中毒和新诊断为1型糖尿病的青少年中罕见的哈曼综合征表现。
Case Rep Pediatr. 2024 Oct 24;2024:1168472. doi: 10.1155/2024/1168472. eCollection 2024.
2
Boerhaave syndrome.博雷尔综合征
Br J Surg. 2024 Aug 30;111(9). doi: 10.1093/bjs/znae216.
3
Spontaneous Pneumomediastinum and Subcutaneous Emphysema Associated With Diabetic Ketoacidosis: A Case Report.自发性纵隔气肿和皮下气肿与糖尿病酮症酸中毒相关:一例报告
Cureus. 2024 May 24;16(5):e61001. doi: 10.7759/cureus.61001. eCollection 2024 May.
4
Spontaneous Pneumomediastinum-Hamman Syndrome.自发性纵隔气肿-哈曼综合征
Dtsch Arztebl Int. 2023 Aug 7;120(31-32):525. doi: 10.3238/arztebl.m2022.0394.
5
Hamman's Syndrome Accompanied by Diabetic Ketoacidosis; a Case Report.伴发糖尿病酮症酸中毒的哈曼综合征;病例报告
Arch Acad Emerg Med. 2022 Aug 21;10(1):e68. doi: 10.22037/aaem.v10i1.1709. eCollection 2022.
6
Pneumomediastinum: Radiological profile and associations of uncommon complication of COVID-19.纵隔气肿:COVID-19罕见并发症的影像学特征及相关因素
J Family Med Prim Care. 2022 Feb;11(2):537-541. doi: 10.4103/jfmpc.jfmpc_1346_21. Epub 2022 Feb 16.
7
Spontaneous pneumomediastinum in diabetic ketoacidosis: A case series of 10 patients.糖尿病酮症酸中毒中的自发性纵隔气肿:10例病例系列报道
World J Emerg Med. 2022;13(2):141-143. doi: 10.5847/wjem.j.1920-8642.2022.029.
8
Images of the month: An incidental finding of spontaneous pneumomediastinum (Hamman's syndrome) secondary to diabetic ketoacidosis during the coronavirus pandemic.本月影像:在新冠疫情期间,继发于糖尿病酮症酸中毒的自发性纵隔气肿(Hamman 综合征)的偶然发现。
Clin Med (Lond). 2020 Nov;20(6):e275-e277. doi: 10.7861/clinmed.2020-0739.
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Spontaneous pneumomediastinum: Experience in 13 patients.自发性纵隔气肿:13例患者的经验
Respir Med Case Rep. 2019 Oct 14;28:100946. doi: 10.1016/j.rmcr.2019.100946. eCollection 2019.
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Respir Physiol Neurobiol. 2019 Jan;259:143-148. doi: 10.1016/j.resp.2018.09.004. Epub 2018 Sep 15.