Sahoo Debananda, Dey Anupam, Bandyopadhyay Tuhin S, Devi Sujata, Dalei Sunita
General Medicine, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND.
Cureus. 2024 Dec 4;16(12):e75124. doi: 10.7759/cureus.75124. eCollection 2024 Dec.
Immune thrombocytopenic purpura (ITP) is an autoimmune self-limiting disorder characterized by a decreased platelet count. Usually, it affects children after viral infections. Adults often develop chronic ITP, but they can also develop ITP following viral infections, which is uncommon. A decrease in platelet synthesis from megakaryocytes and a reduction in platelet half-life appear to cause post-viral thrombocytopenia. Most clinical signs of post-viral thrombocytopenia appear towards the end of the first week of illness, but if they appear after the second week of illness, ITP development should be considered. Although thrombocytopenia is frequently associated with dengue fever, reports of ITP as a presenting symptom are less common. We describe a female patient in her forties who presented with ITP as the initial symptom of dengue fever. The patient was successfully managed with supportive care and platelet transfusions. This case highlights the importance of considering ITP as a potential complication of dengue fever and emphasizes the need for early diagnosis and appropriate management.
免疫性血小板减少性紫癜(ITP)是一种自身免疫性自限性疾病,其特征为血小板计数减少。通常,它在病毒感染后影响儿童。成人常发展为慢性ITP,但他们也可能在病毒感染后发生ITP,不过这种情况并不常见。巨核细胞产生血小板的合成减少以及血小板半衰期缩短似乎会导致病毒感染后血小板减少。病毒感染后血小板减少的大多数临床症状在疾病第一周快结束时出现,但如果在疾病第二周后出现,则应考虑ITP的发生。虽然血小板减少常与登革热相关,但以ITP作为首发症状的报道较少见。我们描述了一名四十多岁的女性患者,她以ITP作为登革热的初始症状。该患者通过支持治疗和血小板输注成功得到治疗。这个病例突出了将ITP视为登革热潜在并发症的重要性,并强调了早期诊断和适当管理的必要性。