Zamani Mohammad Reza, Šácha Pavel
Department of Cell Biology, Faculty of Science, Charles University, Prague, Czech Republic.
Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Prague, Czech Republic.
Heliyon. 2024 Nov 13;10(23):e40386. doi: 10.1016/j.heliyon.2024.e40386. eCollection 2024 Dec 15.
Coronavirus disease 2019 (COVID-19) is a highly contagious viral disease, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It can manifest as mild to severe flu-like and non-flu-like symptoms and signs, which are associated with immune dysfunction and increased mortality. The findings from COVID-19 patients imply a link between immune system abnormalities such as impaired T-cell responses or cytokine imbalances and increased risk for worse clinical outcomes, which has not been fully understood. Owing to the regulatory role of inhibitory immune checkpoints during COVID-19 infection, this review summarizes the available studies concerning the TIM3 as a relatively less characterized immune checkpoint in COVID-19 patients.
2019冠状病毒病（COVID-19）是一种由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的高度传染性病毒性疾病。它可表现为轻度至重度的流感样和非流感样症状及体征，这些症状与免疫功能障碍和死亡率增加有关。COVID-19患者的研究结果表明，免疫系统异常（如T细胞反应受损或细胞因子失衡）与临床预后恶化风险增加之间存在联系，但尚未完全明确。由于抑制性免疫检查点在COVID-19感染过程中的调节作用，本综述总结了关于T细胞免疫球蛋白和粘蛋白结构域3（TIM3）这一在COVID-19患者中特征相对较少的免疫检查点的现有研究。
