Chen Kehan, Yang Hui, Xu Guo, Hu Yunhan, Tian Xue, Qin Song, Jiang Tianyue
School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 211816 China
RSC Med Chem. 2025 Jan 2. doi: 10.1039/d4md00781f.
Topical delivery of therapeutics on the skin can effectively alleviate skin symptoms of psoriasis and reduce systemic toxicity. However, the low delivery efficiency caused by the stratum corneum barrier limits the therapeutic impact. Here, we reported an oligopeptide hydrogel that encapsulates cell-penetrating-peptide (CPP)-decorated curcumin-loaded nanoemulsions (Cur-CNEs) to enhance the skin penetration of curcumin for topical treatment of psoriasis. After being applied to the skin of psoriatic mice, the Cur-CNE embedded oligopeptide hydrogel (Cur-CNEs/Gel) provided a prolonged residue time of Cur-CNEs on the skin lesion. The fluidic and elastic properties of the nanoemulsions enabled them to effectively pass through the interstitial spaces of the stratum corneum, while the CPP decoration further enhanced skin penetration and cellular uptake of Cur-CNEs. The Cur-CNEs/Gel exhibits effective alleviation of the symptoms of psoriasis in mice and provides a promising strategy for topical treatment of psoriasis.
在皮肤上局部递送治疗药物可有效缓解银屑病的皮肤症状并降低全身毒性。然而，角质层屏障导致的低递送效率限制了治疗效果。在此，我们报道了一种寡肽水凝胶，其包裹了穿膜肽（CPP）修饰的载姜黄素纳米乳液（Cur-CNEs），以增强姜黄素的皮肤渗透性用于银屑病的局部治疗。将其应用于银屑病小鼠皮肤后，嵌入Cur-CNEs的寡肽水凝胶（Cur-CNEs/Gel）使Cur-CNEs在皮肤损伤处的残留时间延长。纳米乳液的流体和弹性特性使其能够有效地穿过角质层的间隙，而CPP修饰进一步增强了Cur-CNEs的皮肤渗透性和细胞摄取。Cur-CNEs/Gel在小鼠中表现出对银屑病症状的有效缓解，并为银屑病的局部治疗提供了一种有前景的策略。
