Institute of Materials Science (ICMUV), Universitat de València, c/ Catedràtic José Beltrán 2, 46980 Paterna, Spain; Physics Department, Faculty of Science, Mansoura University, 35516 Mansoura, Egypt.
Institute of Materials Science (ICMUV), Universitat de València, c/ Catedràtic José Beltrán 2, 46980 Paterna, Spain.
Colloids Surf B Biointerfaces. 2021 Jul;203:111764. doi: 10.1016/j.colsurfb.2021.111764. Epub 2021 Apr 20.
Nanoemulsions are kinetically stabilized emulsions with droplet sizes in the nanometer scale. These nanodroplets are able to confine spaces in which reactions of polymerization or precipitation can take place, leading to the formation of particles and capsules that can act as nanocarriers for biomedical applications. This review discusses the different possibilities of using nanoemulsions for preparing biomedical nanocarriers. According to the chemical nature, nanocarriers prepared in nanoemulsions are classified in polymeric, inorganic, or hybrid. The main synthetic strategies for each type are revised, including miniemulsion polymerization, nanoemulsion-solvent evaporation, spontaneous emulsification, sol-gel processes, and combination of different techniques to form multicomponent materials.
纳米乳剂是动力学稳定的乳液，其液滴尺寸在纳米范围内。这些纳米液滴能够限制聚合或沉淀反应发生的空间，从而形成可以作为生物医学应用的纳米载体的颗粒和胶囊。本文综述了利用纳米乳剂制备生物医学纳米载体的不同可能性。根据化学性质，纳米乳剂中制备的纳米载体分为聚合物、无机或杂化。综述了每种类型的主要合成策略，包括细乳液聚合、纳米乳剂-溶剂蒸发、自发乳化、溶胶-凝胶过程以及不同技术的组合以形成多组分材料。
