Pozdniakova T M, Rybachuk V N
Ukr Biokhim Zh (1978). 1985 Jan-Feb;57(1):3-8.
Investigation of fibrin N-terminal disulphide knot (N-DSK) binding with fibrinogen (F) showed, that the F-N-DSK-complex represents growing polymer structure which is soluble at early polymerization stage and forms a solid phase during the further growth. This complex is characterized by constant stoichiometry expressed by formula F (N-DSK)2. A model of the complex structure as a regular copolymer of fibrinogen and N-DSK is proposed, in which neighbouring fibrinogen molecules are clamped with two N-DSK molecules. Such copolymer was never described. Since its formation is caused by specific D-E interdomain binding, it may be considered as a peculiar analogue of fibrin polymer.
对纤维蛋白N端二硫键结（N-DSK）与纤维蛋白原（F）结合的研究表明，F-N-DSK复合物呈现出不断增长的聚合物结构，该结构在聚合早期是可溶的，并在进一步生长过程中形成固相。这种复合物的特征是具有由公式F（N-DSK）2表示的恒定化学计量。提出了一种将该复合物结构作为纤维蛋白原和N-DSK的规则共聚物的模型，其中相邻的纤维蛋白原分子被两个N-DSK分子夹住。从未描述过这种共聚物。由于其形成是由特定的结构域间D-E结合引起的，它可被视为纤维蛋白聚合物的一种特殊类似物。
