Posuwan Nawarat, Wasitthankasem Rujipat, Pimsing Napaporn, Phaengkha Wijittra, Ngamnimit Saranya, Vichaiwattana Preeyaporn, Klinfueng Sirapa, Raksayod Maneerat, Poovorawan Yong
Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chulahorn International College of Medicine, Thammasat University, Rangsit Campus, Patum Thani, Thailand.
J Virus Erad. 2024 Dec 11;10(4):100577. doi: 10.1016/j.jve.2024.100577. eCollection 2024 Dec.
Chronic hepatitis B (HBV) and C (HCV) are major health challenges in Thailand, with Phetchabun province, a known HCV-endemic area, being a key target for elimination efforts. This study aimed to assess HBV prevalence and identify associated risk factors in this province. Data was collected from three cross-sectional population studies: (1) adults in 2015 (n = 1,667, age 30-64 years), (2) young adults in 2017 (n = 1,453, age 18-30 years), both from high HCV-endemic districts, and (3) a province-wide study in 2018 (n = 4,769, age 35-64 years). Plasma samples were tested for HBsAg using the ARCHITECT assay. Results showed HBsAg seropositivity in 3.1 % of young adults in high-endemic districts, with significant associations with age, education, injecting drug use, and MSM behavior. Among adults, HBsAg prevalence was 5.9 %, linked to age and family liver disease history. Province-wide, 6.3 % of adults tested positive, with factors like gender and history of blood donation playing significant roles. Notably, age and blood donation were protective factors against HBV in adults. Analysis revealed a moderate HBV prevalence in those born before Thailand Expanded Program on Immunization (EPI) program, while those born after had rates below 1 %. The findings emphasize distinct HBV transmission patterns in different age groups, influenced by social and behavioral shifts. This knowledge is crucial for effective hepatitis elimination strategies in the Phetchabun province and nationwide.
慢性乙型肝炎（HBV）和丙型肝炎（HCV）是泰国面临的重大健康挑战，碧差汶府作为已知的HCV流行地区，是消除工作的关键目标。本研究旨在评估该省HBV的流行情况并确定相关危险因素。数据收集自三项横断面人群研究：（1）2015年的成年人（n = 1667，年龄30 - 64岁），（2）2017年的年轻人（n = 1453，年龄18 - 30岁），两者均来自HCV高流行区，以及（3）2018年的全省范围研究（n = 4769，年龄35 - 64岁）。使用ARCHITECT检测法对血浆样本进行HBsAg检测。结果显示，高流行区3.1%的年轻人HBsAg血清学阳性，与年龄、教育程度、注射吸毒和男男性行为显著相关。在成年人中，HBsAg患病率为5.9%，与年龄和家族肝病病史有关。在全省范围内，6.3%的成年人检测呈阳性，性别和献血史等因素起重要作用。值得注意的是，年龄和献血是成年人预防HBV的保护因素。分析显示，在泰国扩大免疫规划（EPI）实施之前出生的人群中HBV流行率中等，而之后出生的人群中该率低于1%。研究结果强调了不同年龄组中不同的HBV传播模式，受社会和行为变化影响。这些知识对于碧差汶府及全国有效的肝炎消除策略至关重要。
