Pakhomova V A, Kriukova G N, Pakhomova O O
Ukr Biokhim Zh (1978). 1985 Jan-Feb;57(1):70-3.
The predominance of restored substrates in the bone system and liver of cats under chronic parodontosis evidence for intensification of reproduction properties of NAD-pairs and causes inhibition of glycolysis and activation of gluconeogenesis. A high content of alpha-ketoglutarate and isocitrate in tissues in a result of lipogenesis inhibition. Under the lower rate of glycolysis, activation of proteolysis and transamination reactions amino acids are the major contributors to pyruvate. Under the acute course of the disease with the development of the inflammatory process the quantity of pyruvate grows sharply in the parodont tissue, as well as oxidative properties of NAD-pairs intensify and lipogenesis accelerates. This is confirmed by a decrease in the alpha-ketoglutarate and isocitrate content in the tissues.
慢性牙周病猫的骨骼系统和肝脏中恢复的底物占优势，这证明了NAD对的繁殖特性增强，并导致糖酵解抑制和糖异生激活。由于脂肪生成抑制，组织中α-酮戊二酸和异柠檬酸含量较高。在糖酵解速率较低的情况下，蛋白水解和转氨反应的激活使氨基酸成为丙酮酸的主要来源。在疾病的急性病程中，随着炎症过程的发展，牙周组织中丙酮酸的量急剧增加，NAD对的氧化特性增强，脂肪生成加速。组织中α-酮戊二酸和异柠檬酸含量的降低证实了这一点。
