Silva Brunno Santos de Freitas, Souza Débora Peclat, Fernandes Alessah Carolyna de Andrade, Rodrigues Larissa Rosa Santana, Kujan Omar, Yamamoto-Silva Fernanda Paula
Department of Stomatologic Sciences, School of Dentistry, Federal University of Goiás, Goiânia, Goiás, Brazil.
University of Anápolis, Anápolis, Goiás, Brazil.
Oral Dis. 2025 Jun;31(6):1539-1545. doi: 10.1111/odi.15224. Epub 2025 Jan 6.
To investigate the clinical manifestations of head and neck cancer in patients with Plummer-Vinson syndrome (PVS) and to assess related oral comorbidities.
Case reports covering head and neck cancer manifestations in patients diagnosed with PVS were included Studies were identified through seven main electronic databases (PubMed/MEDLINE, EMBASE, Scopus, Web of Science, CINAHL, LILACS, and LIVIVO), and a search for gray literature was performed using ProQuest Dissertations and Theses and Google Scholar. Independent reviewers applied predefined eligibility criteria in a two-phase selection process.
Out of a total of 19,183 citations identified, seven met the inclusion criteria. Prevalent symptoms included dysphagia and esophageal webs, with atrophic glossitis and angular cheilitis being common oral manifestations. Most patients presented with long-standing iron deficiency anemia. Head and neck cancers predominantly affected the pharynx and tongue borders, with younger age groups notably affected. The overall risk of bias attributable to the quality of the reports was assessed as "low".
Despite the rarity of PVS-related head and neck cancer, this review underscores its association, particularly in younger patients. A thorough examination of dysphagia and oral manifestations in PVS patients is crucial for early detection and prevention of head and neck cancer.
探讨患有普卢默-文森综合征（PVS）的患者头颈部癌症的临床表现，并评估相关的口腔合并症。
纳入了有关诊断为PVS的患者头颈部癌症表现的病例报告。通过七个主要电子数据库（PubMed/MEDLINE、EMBASE、Scopus、Web of Science、CINAHL、LILACS和LIVIVO）进行研究识别，并使用ProQuest Dissertations and Theses以及谷歌学术搜索灰色文献。独立评审人员在两阶段筛选过程中应用预定义的纳入标准。
在总共识别出的19183条引文中，有7条符合纳入标准。常见症状包括吞咽困难和食管蹼，萎缩性舌炎和口角炎是常见的口腔表现。大多数患者患有长期缺铁性贫血。头颈部癌症主要影响咽部和舌边缘，年轻人群受影响尤为明显。归因于报告质量的总体偏倚风险被评估为“低”。
尽管与PVS相关的头颈部癌症罕见，但本综述强调了其关联性，尤其是在年轻患者中。对PVS患者的吞咽困难和口腔表现进行全面检查对于头颈部癌症的早期检测和预防至关重要。
