Fuster V, Bowie E J
Ric Clin Lab. 1979 Oct-Dec;9(4):319-26. doi: 10.1007/BF02904568.
There is experimental evidence that platelets, by interacting with the arterial wall may be important in the initiation of atherosclerosis. This paper describes the results of consecutive experiments indicating that pigs with impaired platelet-blood vessel interaction in the form of von Willebrand's disease are resistant to the development of atherosclerotic plaques. Ongoing experiments in these pigs are providing significant insight into the relationship of the circulating platelets, the endothelial cell and circulating von Willebrand factor, and the reactivity of the arterial wall in the process of atherosclerosis.
有实验证据表明，血小板通过与动脉壁相互作用，可能在动脉粥样硬化的起始过程中起重要作用。本文描述了一系列实验的结果，这些结果表明，患有血管性血友病形式的血小板-血管相互作用受损的猪对动脉粥样硬化斑块的形成具有抗性。对这些猪正在进行的实验正在为深入了解循环血小板、内皮细胞和循环血管性血友病因子之间的关系，以及动脉粥样硬化过程中动脉壁的反应性提供重要线索。
