Sultzer D L, Brinkhous K M, Reddick R L, Griggs T R
Atherosclerosis. 1982 Jun;43(2-3):303-9. doi: 10.1016/0021-9150(82)90031-4.
The extent of coronary and aortic atherosclerosis was examined in pigs following balloon-catheter injury of coronary arteries and subsequent feeding of an atherogenic diet for 4 months. The pigs were either exposed intermittently to 100 ppm carbon monoxide or to ambient air alone. Three types of pigs were used: normals, homozygotes for von Willebrand's disease (bleeders), and heterozygotes (carriers). The 3 types of pigs developed coronary artery intimal lesions of similar thickness. Aortic lesions, quantified as percent of aortic surface involved with sudanophilia and raised fibrous plaques, were slightly less extensive in bleeder pigs than in normals. Carbon monoxide exposure did not increase the thickness of coronary artery intimal lesions, nor did it increase the percent of aortic surface involved with sudanophilia or raised fibrous lesions. These results suggest that exposure to low levels of carbon monoxide does not perceptibly enhance atherogenesis induced by hypercholesterolemia. None of 14 bleeder pigs showed evidence of myocardial infarction, despite significant coronary artery narrowing. Of the 24 normal and carrier pigs, 5 showed myocardial infarction. Four of these 5 pigs were exposed to carbon monoxide, while 1 was not exposed. These findings suggest that exposure to low levels of carbon monoxide may increase the incidence of myocardial infarction and that the absence of von Willebrand factor may be protective.
在猪冠状动脉经球囊导管损伤并随后喂食致动脉粥样化饮食4个月后，检查其冠状动脉和主动脉粥样硬化的程度。这些猪要么间歇性暴露于100 ppm一氧化碳中，要么仅暴露于环境空气中。使用了三种类型的猪：正常猪、血管性血友病纯合子（出血者）和杂合子（携带者）。这三种类型的猪都出现了厚度相似的冠状动脉内膜病变。以苏丹红染色阳性和隆起纤维斑块累及的主动脉表面百分比来量化的主动脉病变，在出血猪中比正常猪略少。一氧化碳暴露并未增加冠状动脉内膜病变的厚度，也未增加苏丹红染色阳性或隆起纤维病变累及的主动脉表面百分比。这些结果表明，暴露于低水平一氧化碳不会明显增强高胆固醇血症诱导的动脉粥样硬化形成。14只出血猪中没有一只出现心肌梗死的迹象，尽管冠状动脉有明显狭窄。在24只正常猪和携带猪中，有5只出现了心肌梗死。这5只猪中有4只暴露于一氧化碳，而1只未暴露。这些发现表明，暴露于低水平一氧化碳可能会增加心肌梗死的发生率，并且血管性血友病因子的缺乏可能具有保护作用。
