Johnson July Mary, Mathew Mary
Centre for Foetal and Perinatal Pathology, Department of Pathology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Forensic Sci Med Pathol. 2025 Jan 6. doi: 10.1007/s12024-024-00936-y.
Neonatal sepsis is an important concern in the field of neonatology, contributing significantly to morbidity and mortality among newborns worldwide. Despite progress in medical care, the accurate diagnosis and comprehension of the pathological underpinnings of neonatal sepsis continue to present challenges. Conventional diagnostic autopsy (CDA) provides unique opportunities to gain insights into the histomorphological alterations associated with neonatal sepsis. There is a paucity of literature regarding autopsy-related histomorphological features in neonatal sepsis in various organs. This narrative review aims to glean data from published literature concerning autopsy-related histomorphological findings in neonatal sepsis, which would aid in understanding organ-related pathological changes and assisting pathologists in determining the exact cause of death.
新生儿败血症是新生儿学领域的一个重要问题，在全球范围内对新生儿的发病率和死亡率有重大影响。尽管医疗护理取得了进展，但新生儿败血症的准确诊断和对其病理基础的理解仍然面临挑战。传统诊断尸检（CDA）为深入了解与新生儿败血症相关的组织形态学改变提供了独特的机会。关于新生儿败血症在各个器官中与尸检相关的组织形态学特征的文献较少。本叙述性综述旨在从已发表的文献中收集有关新生儿败血症与尸检相关的组织形态学发现的数据，这将有助于理解器官相关的病理变化，并协助病理学家确定确切的死亡原因。
