Denson Damian J, Tesfaye Casey Langer, Glusberg Daniela, Schoua-Glusberg Alisú, Betley Valerie, Gale Bryan, Cardo Jessica, Frew Paula M, McLellan-Lemal Eleanor, O'Connor Siobhán M, McNicholl Janet M
Division of HIV Prevention, Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, 1600 Clifton Road NE, Mailstop US8-4, Atlanta, GA, 30333, USA.
Research Support Services, Inc., Evanston, USA.
J Racial Ethn Health Disparities. 2025 Jan 6. doi: 10.1007/s40615-024-02263-y.
Young Black women in the southern US face a high HIV burden. While daily oral HIV pre-exposure prophylaxis (PrEP) can effectively prevent HIV, its use is low among Black women. The acceptability of and perceived intention to use emerging PrEP products among young Black women in the southern US are not well understood. Non-oral PrEP alternatives could address challenges to PrEP uptake and reduce health disparities. We conducted virtual semi-structured interviews with Black women aged 18-34 in Atlanta, GA; Baton Rouge, LA; and Jackson, MS, to explore their perspectives on three emerging PrEP products: a long-acting injection, a subdermal implant, and a dual-purpose contraception and HIV prevention intravaginal ring. Seventy-five interviews were conducted from January to October 2021 and analyzed using inductive thematic analysis with NVivo software. Most participants were open to using medication to prevent HIV. The intravaginal ring was the most preferred, primarily due to its dual-purpose function, although it was also frequently rejected. The long-acting injection was the second most preferred and least rejected, perceived as the least invasive. The skin implant was the least preferred and most rejected, viewed as the most invasive. Our findings highlight the need for multiple PrEP options to meet individual preferences. Detailed descriptions, instructions, and experiential learning methods are crucial for choosing non-oral PrEP modalities. Practitioners should address questions and offer peer-based learning opportunities. Designing and promoting PrEP strategies for young Black women should involve close consultation with these consumers.
美国南部的年轻黑人女性面临着沉重的艾滋病毒负担。虽然每日口服艾滋病毒暴露前预防药物（PrEP）可以有效预防艾滋病毒，但黑人女性对其使用率较低。美国南部年轻黑人女性对新兴PrEP产品的接受度和使用意愿尚不清楚。非口服PrEP替代品可以应对PrEP使用方面的挑战并减少健康差距。我们对佐治亚州亚特兰大、路易斯安那州巴吞鲁日和密西西比州杰克逊的18至34岁黑人女性进行了虚拟半结构化访谈，以探讨她们对三种新兴PrEP产品的看法：长效注射剂、皮下植入物和兼具避孕与艾滋病毒预防功能的阴道环。2021年1月至10月进行了75次访谈，并使用NVivo软件进行归纳主题分析。大多数参与者愿意使用药物预防艾滋病毒。阴道环是最受欢迎的，主要是因为它具有双重功能，不过也经常被拒绝。长效注射剂是第二受欢迎且被拒绝最少的，被认为侵入性最小。皮肤植入物是最不受欢迎且被拒绝最多的，被视为侵入性最大。我们的研究结果强调需要多种PrEP选择来满足个人偏好。详细的描述、说明和体验式学习方法对于选择非口服PrEP方式至关重要。从业者应解答问题并提供基于同伴的学习机会。为年轻黑人女性设计和推广PrEP策略应与这些消费者密切协商。
