Shestopalov A V, Krolenko E V, Nedorubov A A, Borisenko O V, Popruga K E, Makarov V V, Yudin S M, Gaponov A M, Rumyantsev S A
Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Health of the Russian Federation, Moscow, Russia.
Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):280-286. doi: 10.1007/s10517-025-06321-1. Epub 2025 Jan 6.
Changes in the lipid and carbohydrate metabolism, adipokines, and growth factors during the development of metabolic disorders were studied in three mouse models: C57BL/6 (alimentary obesity), db/db (leptin-resistant obesity), and NOD (diabetes mellitus) lines. In the group of alimentary obesity, moderate fatty infiltration of the liver and hypertrophy of the adipose tissue, hyperglycemia, and increased concentrations of adiponectin, transforming growth factor β1 (TGF-β1), leptin, and cholesterol were detected. In the group of leptin-resistant obesity, multiple pathological changes in tissues, severe hyperglycemia and hyperleptinemia, hyperinsulinemia, and reduced concentrations of triglycerides, adiponectin, myostatin, and TGF-β1 were detected. In NOD mice, reduced number of insulin-positive β cells, hyperinsulinemia, and a decrease in adiponectin, TGF-β1, leptin, and myostatin concentrations were detected.
在三种小鼠模型中研究了代谢紊乱发展过程中脂质和碳水化合物代谢、脂肪因子及生长因子的变化，这三种小鼠模型分别是：C57BL/6（饮食性肥胖）、db/db（瘦素抵抗性肥胖）和NOD（糖尿病）品系。在饮食性肥胖组中，检测到肝脏有中度脂肪浸润、脂肪组织肥大、高血糖，以及脂联素、转化生长因子β1（TGF-β1）、瘦素和胆固醇浓度升高。在瘦素抵抗性肥胖组中，检测到组织出现多种病理变化、严重高血糖和高瘦素血症、高胰岛素血症，以及甘油三酯、脂联素、肌肉生长抑制素和TGF-β1浓度降低。在NOD小鼠中，检测到胰岛素阳性β细胞数量减少、高胰岛素血症，以及脂联素、TGF-β1、瘦素和肌肉生长抑制素浓度降低。
