Masopust David, Sivula Christine P, Jameson Stephen C
Department of Microbiology and Immunology, Center for Immunology, University of Minnesota Medical School, Minneapolis, MN 55455;
Research Animal Resources, University of Minnesota, Minneapolis, MN 55455; and.
J Immunol. 2017 Jul 15;199(2):383-388. doi: 10.4049/jimmunol.1700453.
Mouse models have enabled breakthroughs in our understanding of the immune system, but it has become increasingly popular to emphasize their shortcomings when translating observations to humans. This review provides a brief summary of mouse natural history, husbandry, and the pros and cons of pursuing basic research in mice versus humans. Opportunities are discussed for extending the predictive translational value of mouse research, with an emphasis on exploitation of a "dirty" mouse model that better mimics the diverse infectious history that is typical of most humans.
小鼠模型使我们在免疫系统的理解上取得了突破，但在将观察结果转化到人类时，强调其缺点变得越来越普遍。本综述简要总结了小鼠的自然史、饲养管理，以及在小鼠和人类中进行基础研究的利弊。文中讨论了扩展小鼠研究预测性转化价值的机会，重点是利用一种“脏”小鼠模型，该模型能更好地模拟大多数人类典型的多样感染史。
