Zhao Sijia, Wu Wenjun, Song Wenyan, Zhou Qunyan, Cheng Haiyan, Deng Shukun, Zhao Jianxin, Zhang Hao, Chen Wei, Wang Hongchao
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
Gut Microbes. 2025 Dec;17(1):2442038. doi: 10.1080/19490976.2024.2442038. Epub 2024 Dec 31.
Changes in the gut microbiota are associated with obesity and may influence weight loss. We are currently implementing a sustained multidisciplinary collaborative weight management (MCWM) approach to weight loss. We report significant improvements in participant health status after 6 months, along with alterations in the structure, interactions, and metabolic functions of the microbiota. We observed an enrichment of the gut symbiont in obese subjects, which was significantly correlated with clinical indicators and contributed significantly to random forest (RF) classification, and revealed its correlation with bile acid metabolism. Experimental results indicate that impairs weight loss in diet-modified obese mice by altering the gut microbiota structure and influencing bile acid metabolism. The findings of this study highlight the significant role of the gut microbiota in obese patients and establishes a more substantial scientific foundation for the prevention and management of obesity.
肠道微生物群的变化与肥胖相关，可能会影响体重减轻。我们目前正在实施一种持续的多学科协作体重管理（MCWM）方法来减轻体重。我们报告了6个月后参与者健康状况的显著改善，以及微生物群的结构、相互作用和代谢功能的改变。我们观察到肥胖受试者肠道共生菌的富集，这与临床指标显著相关，并对随机森林（RF）分类有显著贡献，还揭示了其与胆汁酸代谢的相关性。实验结果表明，通过改变肠道微生物群结构和影响胆汁酸代谢，会损害饮食改良肥胖小鼠的体重减轻。本研究结果突出了肠道微生物群在肥胖患者中的重要作用，并为肥胖的预防和管理奠定了更坚实的科学基础。
