Zhou Qiao, Yang Yu-Long, Wang Jia-Feng, Dong Yu-Chao, Hou Jin, Guo Meng, Zhang Wei, Liu Yan-Fang, Bai Chong
Department of Respiratory and Critical Care Medicine.
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P. R. China.
Am J Respir Cell Mol Biol. 2025 Jul;73(1):37-48. doi: 10.1165/rcmb.2024-0407OC.
Identifying inflammation-induced leukocyte subsets and their derived circulating factors has been instrumental in understanding the progression of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). Nevertheless, how primary inflammation-induced nonleukocyte populations in distal organs contribute to ALI/ARDS remains poorly defined. Here, we report one population of erythroblast-like cells (Ter-cells) deriving from megakaryocyte-erythroid progenitor cells with a unique Ter-119CD45CD71 phenotype in ALI/ARDS. Ter-cells induced by the spleen are chemoattracted into the lung to inhibit the progression of ALI by secreting the neurotrophic factor artemin into the blood and BAL fluid. blockade of Ter-cell-derived artemin aggravates lung injury, and artemin deficiency abolishes Ter-cells' antiinflammatory ability. We confirm the presence of circulating artemin in patients with ARDS and show that significantly elevated artemin correlates with good prognosis. We propose that Ter-cells and the secreted artemin play important roles in ALI/ARDS, with prognostic and therapeutic implications.
识别炎症诱导的白细胞亚群及其衍生的循环因子有助于理解急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）的进展。然而，远端器官中由原发性炎症诱导的非白细胞群体如何导致ALI/ARDS仍不清楚。在此，我们报告了在ALI/ARDS中源自巨核细胞-红系祖细胞的一类具有独特Ter-119CD45CD71表型的成红细胞样细胞（Ter细胞）。脾脏诱导的Ter细胞被趋化至肺内，通过向血液和支气管肺泡灌洗液中分泌神经营养因子Artemin来抑制ALI的进展。阻断Ter细胞衍生的Artemin会加重肺损伤，而Artemin缺乏会消除Ter细胞的抗炎能力。我们证实ARDS患者血液中存在循环Artemin，并表明Artemin显著升高与良好预后相关。我们提出Ter细胞和分泌的Artemin在ALI/ARDS中起重要作用，具有预后和治疗意义。
