Angerer Markus, Zecha Henrik, Wülfing Christian, Dieckmann Klaus Peter
Department of Urology, Asklepios Klinik Altona, Hamburg, Germany.
Department of Urology, Albertinen Krankenhaus, Hamburg, Germany.
Urol Int. 2025;109(3):299-306. doi: 10.1159/000542431. Epub 2025 Jan 6.
Half of all patients with testicular germ cell tumors (GCTs) present with metastases to retroperitoneal lymph nodes or visceral organs. Inguinal metastases (I/Ms) are very rare. We aimed to evaluate the relative frequency and clinical features of I/Ms and look for predisposing factors.
A cohort of 740 GCT patients treated between 2010 and 2022 was analyzed. The frequency of I/M and their clinical features were statistically compared among the subgroups.
Eight patients had I/M, with a median age of 55 years, all of whom had primary seminoma and six had previous groin surgery. The relative frequency of I/M is 1.1% and 8.3% in the GCT patient cohort and the metastasized seminoma subgroup, respectively. All patients were cured, six underwent surgery and additional chemotherapy, and two received cisplatin-based chemotherapy alone.
I/Ms occur in approximately 1% of GCT patients. Prior groin surgery, bulky retroperitoneal metastases, and possibly histology of seminoma represent risk factors for I/M. The presence of I/M does not adversely affect prognosis, and all cases can be cured with standard therapeutic measures. Lymph node excision may be required to establish the diagnosis. In patients with risk factors, follow-up examinations should include the groins.
所有睾丸生殖细胞肿瘤（GCT）患者中有一半会出现腹膜后淋巴结或内脏器官转移。腹股沟转移（I/M）非常罕见。我们旨在评估I/M的相对频率和临床特征，并寻找易感因素。
分析了2010年至2022年间接受治疗的740例GCT患者队列。对各亚组中I/M的频率及其临床特征进行了统计学比较。
8例患者出现I/M，中位年龄为55岁，所有患者均为原发性精原细胞瘤，6例曾接受腹股沟手术。I/M在GCT患者队列和转移性精原细胞瘤亚组中的相对频率分别为1.1%和8.3%。所有患者均治愈，6例接受了手术及额外化疗，2例仅接受了以顺铂为基础的化疗。
I/M发生在约1%的GCT患者中。既往腹股沟手术、巨大腹膜后转移以及可能的精原细胞瘤组织学表现是I/M的危险因素。I/M的存在不会对预后产生不利影响，所有病例均可通过标准治疗措施治愈。可能需要进行淋巴结切除以明确诊断。对于有危险因素的患者，随访检查应包括腹股沟。
