Fenton Tanis R, Alshaikh Belal, Kusuda Satoshi, Helenius Kjell, Modi Neena, Norman Mikael, Lui Kei, Lehtonen Liisa, Battin Malcolm, Klinger Gil, Vento Maximo, Lastrucci Vieri, Gagliardi Luigi, Adams Mark, Marba Sérgio T M, Isayama Tetsuya, Hakansson Stellan, Bassler Dirk, Shah Prakesh S
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada.
Arch Dis Child Fetal Neonatal Ed. 2025 Jun 19;110(4):401-408. doi: 10.1136/archdischild-2024-327845.
Size at birth is a key indicator of in utero growth. Our objective was to generate sex-specific percentiles for birth weight and head circumference in neonates born between 22 and 29 weeks gestation from pregnancies without hypertension or diabetes and assess differences between vaginal and caesarean births and between singletons and twins.
We used data from 12 countries participating in the International Network for Evaluating Outcomes in Neonates database from 2007 to 2021. We excluded data that were influenced by truncation with 1500g birth weight cut-offs in databases and neonates with major congenital anomalies or born to mothers with hypertension or diabetes.
After exclusions, 132 727 neonates contributed to birth weight and 65 406 contributed to head circumference. The percentiles of birth weight were similar between countries at the 50th and 90th percentiles, though variability was noted in the lower percentiles from countries with smaller sample sizes. Head circumference percentiles were comparable between countries. Caesarean births had birth weights similar to vaginal births until 26 weeks after which the weight at 10th percentile diverged by approximately 239 g at 29 weeks. Vaginal births had birth weights very similar to Hadlock's intrauterine estimated fetal weights. There were no differences in head circumference between vaginal and caesarean births and between singletons and twins.
We present updated information on weight and head circumference at birth for preterm neonates of 22-29 weeks gestation born to mothers without hypertension or diabetes derived from a large multicountry cohort. Research is needed to explore the predictive value of these birth size data for health and developmental outcomes.
出生时的大小是子宫内生长的关键指标。我们的目的是为妊娠22至29周出生、母亲无高血压或糖尿病的新生儿生成出生体重和头围的性别特异性百分位数，并评估阴道分娩和剖宫产之间以及单胎和双胎之间的差异。
我们使用了2007年至2021年参与国际新生儿结局评估网络数据库的12个国家的数据。我们排除了受数据库中1500g出生体重截断影响的数据以及患有重大先天性异常或母亲患有高血压或糖尿病的新生儿的数据。
排除后，132727例新生儿提供了出生体重数据，65406例新生儿提供了头围数据。各国在第50和第90百分位数的出生体重百分位数相似，不过样本量较小的国家在较低百分位数处存在差异。各国的头围百分位数具有可比性。剖宫产出生体重在26周前与阴道分娩相似，之后在29周时第10百分位数的体重相差约239g。阴道分娩的出生体重与哈德洛克宫内估计胎儿体重非常相似。阴道分娩和剖宫产之间以及单胎和双胎之间的头围没有差异。
我们提供了来自一个大型多国队列的、母亲无高血压或糖尿病的22至29周妊娠早产新生儿出生体重和头围的最新信息。需要开展研究来探索这些出生大小数据对健康和发育结局的预测价值。
