Masui Yoshiho, Nishiguchi Tomizo, Takehara Kei, Kamo Aki, Shinya Mitsuhisa, Kawamura Takakazu
Department of Perinatal Maternal and Child Medical Center, Shizuoka Children's Hospital, 860 Urushiyama, Aoi-Ku, Shizuoka-Shi, Shizuoka, 420-8660, Japan.
Department of Obstetrics and Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
Arch Gynecol Obstet. 2025 Mar;311(3):893-902. doi: 10.1007/s00404-024-07887-3. Epub 2025 Jan 7.
This study aimed to investigate the usefulness of emergency cerclage for pregnant women with bulging fetal membranes, as indicated by our original noninvasive clinical scoring system.
This was a retrospective study of pregnant women who underwent emergency cerclage for bulging fetal membranes within 28 weeks. The primary outcome was the continuation of pregnancy at 34 gestational weeks in singleton pregnancies and 32 gestational weeks in twin pregnancies. The secondary outcomes were the interval from cerclage to delivery, neonatal mortality, and morbidity. To determine surgical indication, we used the original clinical scoring system comprising cervical shortening or dilation degree and uterine contraction levels.
128 women were included in this study (112 singleton pregnancies and 16 twin pregnancies). The continuation of pregnancy rate as the primary outcome (Cerclage Success group) was 78.6% in singleton pregnancies and 75% in twin pregnancies. The median interval between cerclage and delivery was 94 days in singleton pregnancies and 78 days in twin pregnancies. Approximately 85% of the babies weighed ≥ 1500 g at birth. Neonatal mortality occurred in only one case, and nine singletons in the Cerclage Failure group had severe neonatal morbidities. According to multivariate analysis of prognostic factors in the Cerclage Failure group, only the serum C-reactive protein level at 1 week postoperatively was an independent prognostic factor (odds ratio: 9.75; 95% confidence interval: 2.99-31.8; p < 0.01).
Emergency cerclage, performed under the indications of our original noninvasive clinical scoring system, led to favorable outcomes.
本研究旨在探讨根据我们最初的非侵入性临床评分系统,对胎膜膨出的孕妇进行紧急宫颈环扎术的有效性。
这是一项对28周内接受胎膜膨出紧急宫颈环扎术的孕妇的回顾性研究。主要结局是单胎妊娠34孕周和双胎妊娠32孕周时的妊娠持续情况。次要结局是从环扎到分娩的间隔时间、新生儿死亡率和发病率。为确定手术指征,我们使用了包括宫颈缩短或扩张程度以及子宫收缩水平的原始临床评分系统。
本研究纳入了128名女性(112名单胎妊娠和16例双胎妊娠)。作为主要结局的妊娠持续率(宫颈环扎成功组)在单胎妊娠中为78.6%,在双胎妊娠中为75%。单胎妊娠中环扎与分娩之间的中位间隔时间为94天,双胎妊娠中为78天。约85%的婴儿出生时体重≥1500g。仅1例发生新生儿死亡,宫颈环扎失败组中有9名单胎婴儿有严重的新生儿疾病。根据宫颈环扎失败组预后因素的多变量分析,仅术后1周的血清C反应蛋白水平是独立的预后因素(比值比:9.75;95%置信区间:2.99 - 31.8;p < 0.01)。
在我们最初的非侵入性临床评分系统的指征下进行的紧急宫颈环扎术取得了良好的效果。