Mi Qian, Wu Xiaoli, Chen Yuhe, Meng Wenxia
Departments of Oral Medicine, Stomatological Hospital, School of Stomatology, Southern Medical University, Guangzhou, Guangdong Province, China.
Inflamm Res. 2025 Jan 7;74(1):10. doi: 10.1007/s00011-024-01990-6.
Mucosal-associated invariant T (MAIT) cells, a type of T lymphocytes with innate-like characteristics, are crucial in bridging innate and adaptive immunity. When activated, MAIT cells release various inflammatory molecules and swiftly respond to antigens. Notably, numerous studies highlight the significant impact of MAIT cells on tumors and various immune disorders by influencing the immune microenvironment. Oral lichen planus (OLP) is an immune-mediated inflammatory condition mainly involving T lymphocytes. Previous research primarily focused on T cells alone, neglecting the broader immune environment. However, there is a current growing recognition of the complex interactions among multiple immune cells and inflammatory factors in patients with OLP. This immune microenvironment comprises T lymphocytes, fibroblasts, keratinocytes, dendritic cells, macrophages, inflammation-related cytokines, and chemokines, orchestrating intricate interactions that contribute to OLP initiation and persistence. Therefore, this review consolidates current research on the interplay between MAIT cells and other immune cells within the OLP microenvironment. We also delve into potential mechanisms through which MAIT cells regulate inflammation in patients with OLP, aiming to further explore the role of MAIT cells in these patients.
黏膜相关恒定T（MAIT）细胞是一类具有固有样特征的T淋巴细胞，在连接固有免疫和适应性免疫方面至关重要。激活后，MAIT细胞会释放各种炎症分子，并迅速对抗原作出反应。值得注意的是，众多研究强调了MAIT细胞通过影响免疫微环境对肿瘤和各种免疫紊乱产生的重大影响。口腔扁平苔藓（OLP）是一种主要涉及T淋巴细胞的免疫介导炎症性疾病。以往研究主要仅关注T细胞，而忽略了更广泛的免疫环境。然而，目前人们越来越认识到OLP患者体内多种免疫细胞和炎症因子之间存在复杂的相互作用。这种免疫微环境由T淋巴细胞、成纤维细胞、角质形成细胞、树突状细胞、巨噬细胞、炎症相关细胞因子和趋化因子组成，它们协同进行复杂的相互作用，促成OLP的发生和持续存在。因此，本综述整合了目前关于MAIT细胞与OLP微环境中其他免疫细胞之间相互作用的研究。我们还深入探讨了MAIT细胞调节OLP患者炎症的潜在机制，旨在进一步探究MAIT细胞在这些患者中的作用。
