Emanuilov A I, Shirina E S, Masliukov P M
Yaroslavl State Medical University, Ministry of Health of the Russian Federation, Yaroslavl, Russia.
Bull Exp Biol Med. 2024 Dec;178(2):181-183. doi: 10.1007/s10517-025-06303-3. Epub 2025 Jan 7.
The expression of somatostatin receptors (SSTRs) of types 1, 2, and 5 was studied in the small intestine of rats from different age groups (1, 10, 20, 30, 60 days, and 2-year-old) using Western blotting. The expression of SSTR1, SSTR2, and SSTR5 increased in the first 30 days of life, but decreased in older rats compared to 2-month-old animals. These findings suggest that there is differential expression of SSTRs during age-related development of the small intestine. Further studies will determine the role of individual SSTRs in the growth and development of target organs.
采用蛋白质印迹法研究了不同年龄组（1日龄、10日龄、20日龄、30日龄、60日龄和2岁）大鼠小肠中1型、2型和5型生长抑素受体（SSTRs）的表达情况。SSTR1、SSTR2和SSTR5的表达在出生后的前30天增加，但与2月龄动物相比，老年大鼠的表达降低。这些发现表明，在小肠与年龄相关的发育过程中，SSTRs存在差异表达。进一步的研究将确定各个SSTRs在靶器官生长和发育中的作用。
