Papantoniou Konstantinos, Aggeletopoulou Ioanna, Pastras Ploutarchos, Triantos Christos
Division of Gastroenterology, Department of Internal Medicine, University of Patras, 26504 Patras, Greece.
Biology (Basel). 2025 May 16;14(5):558. doi: 10.3390/biology14050558.
The gastrointestinal (GI) tract is responsible for food digestion and host protection from harmful stimuli; however, its function as an endocrine organ is also well documented. Somatostatin (SST) was first discovered in the hypothalamus, but the GI tract is its main producer and target organ. SST is a potent inhibitor of many GI functions, including peristalsis, hormone secretion, and gastric acid production, while its anti-inflammatory effects contribute to the integrity of the intestinal barrier. These data make SST and its analogs useful agents in clinical practice. As our understanding of SST metabolism and function evolves, their use in a wide variety of medical conditions can improve patient care.
胃肠道负责食物消化以及保护机体免受有害刺激；然而，其作为内分泌器官的功能也有充分记载。生长抑素（SST）最初是在下丘脑中发现的，但胃肠道是其主要产生部位和靶器官。SST是许多胃肠功能的强效抑制剂，包括蠕动、激素分泌和胃酸分泌，而其抗炎作用有助于维持肠道屏障的完整性。这些数据使SST及其类似物成为临床实践中的有用药物。随着我们对SST代谢和功能的认识不断发展，它们在多种医疗状况中的应用可以改善患者护理。
