Chang Hyun-Ha, Nam Hyun-Ju, Kim Hyun Sook, Park Kyung-Hwa, Bae Sohyun, Kim Yoonjung, Kim Shin-Woo, Jung Sook In
Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
Department of Infectious Diseases, Chonnam National University Medical School, Gwangju, Korea.
Infect Chemother. 2024 Dec;56(4):551-554. doi: 10.3947/ic.2024.0126.
This retrospective study analyzed medical records of 1,392 people living with HIV (PLWH) diagnosed with latent tuberculosis infection (LTBI) at two provincial central hospitals from 2011 to 2022. LTBI was diagnosed in 152 patients (10.9%) patients aged ≥18 years. Among the 113 patients who initiated treatment, 96 (85.0%) completed isoniazid therapy, while 17 (15.0%) discontinued due to patient refusal, liver function test abnormalities, and other reasons. During a mean follow-up period of 55.0±31.0 months, two cases of active tuberculosis were reported in both the treatment non-completion group (3.6%) and the completion group (2.1%). This study provides recent real-world insights into LTBI treatment among PLWH in Korea.
这项回顾性研究分析了2011年至2022年期间在两家省级中心医院被诊断为潜伏性结核感染（LTBI）的1392例艾滋病毒感染者（PLWH）的病历。152例（10.9%）年龄≥18岁的患者被诊断为LTBI。在开始治疗的113例患者中，96例（85.0%）完成了异烟肼治疗，而17例（15.0%）因患者拒绝、肝功能检查异常及其他原因停药。在平均55.0±31.0个月的随访期内，治疗未完成组（3.6%）和完成组（2.1%）均报告了2例活动性结核病例。本研究提供了韩国PLWH中LTBI治疗的最新真实世界见解。
