Henriksson B A, Biber B, Martner J, Pontén J, Werner O
Acta Anaesthesiol Scand. 1985 Jan;29(1):90-4. doi: 10.1111/j.1399-6576.1985.tb02165.x.
In chloralose-anaesthetized dogs the carotid sinuses were bilaterally perfused with blood from a femoral artery, either at systemic arterial pressure through a direct by-pass or with a pump in order to control the sinus pressure. Influences from cardiac receptors and aortic baroreceptors were eliminated by denervation. Administration of enflurane (1.6% end-tidal concentration) with the presence of barostatic modulation, i.e. the carotid sinuses were perfused at prevailing systemic arterial pressure, reduced cardiac performance (cardiac output, cardiac contractility, heart rate and left ventricular stroke work) and mean arterial pressure. When barostatic compensation of enflurane-induced circulatory changes was prevented by maintaining sinus perfusion pressure constant at the pre-enflurane level, these haemodynamic alterations, with the exception of cardiac output, were significantly more pronounced. Furthermore, systemic vascular resistance decreased. We conclude that barostatic reflexes significantly modify cardiovascular depressive effects of enflurane.
在水合氯醛麻醉的犬中，通过直接旁路或使用泵以全身动脉压从股动脉向双侧颈动脉窦灌注血液，以控制窦压力。通过去神经支配消除心脏感受器和主动脉压力感受器的影响。在存在静压调节的情况下给予安氟醚（呼气末浓度为1.6%），即颈动脉窦在当时的全身动脉压下进行灌注，会降低心脏功能（心输出量、心脏收缩力、心率和左心室搏功）以及平均动脉压。当通过将窦灌注压力维持在安氟醚给药前的水平恒定来防止对安氟醚引起的循环变化进行静压补偿时，除心输出量外，这些血流动力学改变明显更为显著。此外，全身血管阻力降低。我们得出结论，静压反射显著改变了安氟醚的心血管抑制作用。
